PMID: 2061552Apr 1, 1991Paper

Methylthiazolidine-4-carboxylate for treatment of acute T-2 toxin exposure

Journal of Applied Toxicology : JAT
R F Fricke, J Jorge

Abstract

The effect of T-2 toxin on hepatic glutathione content and the protective effect of 2-methyl-thiazolidine-4-carboxylate (MTCA), an L-cysteine prodrug, were studied in mice. Acute exposure to T-2 toxin (4 mg kg-1, s.c.) resulted in a progressive decrease in glutathione content, reaching a minimum 6-8 h after toxin administration. Because T-2 toxin caused decreased food consumption, a condition known to deplete hepatic glutathione, glutathione was measured in both fed and fasted control and toxin-treated mice. Glutathione content (mumol g-1 tissue) was 9.01 +/- 0.66 (control) and 4.26 +/- 0.41 (toxin) for fed mice, 4.45 +/- 0.39 (control) and 2.45 +/- 0.26 (toxin) for 16-h fasted mice, and 7.18 +/- 0.26 (control) and 3.76 +/- 0.65 (toxin) for mice fed before, but fasted after exposure to toxin. In all cases, toxin treatment resulted in significant decreases in glutathione content compared to controls. Treatment of T-2-intoxicated mice with MTCA (750 mg kg-1, i.p.) not only maintained glutathione content at control levels or higher but significantly improved survival as well. Therefore, the toxicity and lethality of T-2 toxin may be associated with decreased hepatic glutathione content, since MTCA maintained glutathione content an...Continue Reading

References

Jan 1, 1978·International Review of Cytology·N S Kosower, E M Kosower
Dec 1, 1979·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·G O EmeroleR L Dixon
Sep 30, 1985·Toxicology and Applied Pharmacology·J G PaceR W Wannemacher
Nov 1, 1973·CRC Critical Reviews in Toxicology·R O Rechnagel, E A Glende
Apr 8, 1974·Biochemical and Biophysical Research Communications·C M Wei, C S McLaughlin
Dec 1, 1984·Toxicology and Applied Pharmacology·T M CosgriffR E Dinterman
Sep 30, 1983·Toxicology and Applied Pharmacology·R SegalB Yagen
Jan 1, 1981·Microbiology and Immunology·S SakaguchiO Sakaguchi

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Citations

Mar 1, 1994·Zentralblatt für Veterinärmedizin. Reihe A·A F RizzoE Elovaara
Mar 14, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Julia E DvorskaPeter F Surai
Jan 17, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Mona AgrawalP V Lakshmana Rao
Jan 24, 2013·Toxicon : Official Journal of the International Society on Toxinology·Mahdi Balali-MoodLeila Etemad
Jun 10, 2003·Journal of Applied Toxicology : JAT·Brian M Paddle

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