Methyltransferase and phospholipase A2 activity in the cell membrane of neutrophils and lymphocytes from patients with Behçet's disease, systemic lupus erythematosus, and rheumatoid arthritis

Clinica Chimica Acta; International Journal of Clinical Chemistry
Y NiwaS Taniguchi

Abstract

Phospholipid methylation and phospholipase A2 activation in the membrane of neutrophils and lymphocytes, which participate in the induction of cell activation, were assessed in patients with Behçet's disease, systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA). [3H-methyl] incorporation and phospholipase A2 activity of neutrophils from active cases of Behçet's disease and RA were significantly increased compared with normal controls. In lymphocytes from the patients with active Behçet's disease and RA, a significant increase in methyltransferase activity and a marked enhancement of phospholipase activity were found. A modest increase in these two membrane phospholipid enzyme activities was observed in lymphocytes of patients with active SLE. In addition, these enzyme activities were significantly enhanced in normal leukocytes preincubated with serum from patients with active SLE and malignant RA. The potentiated functions of neutrophils and lymphocyte abnormalities in the patients tested thus seem to be at least partly due to an increase in these enzymatic activities in the cell membrane.

References

Jan 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·F HirataJ Axelrod
Oct 25, 1975·Lancet·N Matsumura, Y Mizushima
May 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·F Hirata, J Axelrod
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·M C PikeR Snyderman
Jun 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·F HirataJ Axelrod
Mar 30, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·Y PachecoH Pacheco
Sep 1, 1965·Annals of the Rheumatic Diseases·T ShimizuY Oshima
May 1, 1971·Analytical Biochemistry·F SalvatoreS K Shapiro
Jun 23, 1971·Nature: New Biology·J B Smith, A L Willis
Nov 30, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·A F PrigentM Perrin-Fayolle
May 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·F HirataA D Steinberg
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T IshizakaJ Axelrod
Mar 13, 1980·Biochemical and Biophysical Research Communications·F T CrewsR P Siraganian
Sep 5, 1980·Science·F Hirata, J Axelrod
Jul 1, 1983·The Biochemical Journal·J M Mato, S Alemany
Oct 1, 1984·Archives of Biochemistry and Biophysics·Y NiwaS Taniguchi
Jan 16, 1984·Clinica Chimica Acta; International Journal of Clinical Chemistry·P FonluptH Pachéco
May 1, 1983·Arthritis and Rheumatism·S B AbramsonG Weissmann
May 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·F HirataJ Axelrod
Feb 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·F HirataM J Waxdal
Mar 1, 1982·Molecular Immunology·S ToyoshimaM J Waxdal
Nov 1, 1982·Arthritis and Rheumatism·E M TanR J Winchester
Feb 1, 1954·The American Journal of Medicine·M BEVANSC RAGAN

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Citations

Apr 1, 1990·Inflammation·P VadasB Sternby
Sep 1, 1993·International Journal of Biometeorology·Y NiwaT Kanoh
Jun 12, 1995·European Journal of Pharmacology·K TanakaT Yoshida
Mar 22, 2014·PloS One·Marta Krystyna KosinskaJuergen Steinmeyer
Jan 8, 2013·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Martin AringerMin Ae Lee-Kirsch
Mar 13, 2003·Lupus·I SekigawaH Hashimoto
Sep 1, 1990·JPEN. Journal of Parenteral and Enteral Nutrition·J E Kinsella
Aug 30, 2005·Annals of the New York Academy of Sciences·Guido Valesini, Cristiano Alessandri
Sep 1, 1994·The Journal of International Medical Research·K MikawaY Niwa
Oct 1, 1994·Prostaglandins, Leukotrienes, and Essential Fatty Acids·K MikawaY Niwa

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