PMID: 43366Dec 1, 1979

Methysergide induces selective potentiation in cholinergic contractions of the guinea-pig vas deferens by facilitating acetylcholine release

The Journal of Pharmacy and Pharmacology
T Katsuragi, T Furukawa

Abstract

Methysergide (3 x 10(-6) M) enhanced the contractile responses of the isolated stripped vas deferens of guinea-pig to acetylchline(ACh) and arecoline, but not those to noradrenaline, tyramine and bradykinin. Methysergide (3 x 10(-5) M) suppressed the contraction elicited by noradrenaline or histamine. The methysergide-induced potentiation of the response to ACh was prevented by pre-addition of hemicholinium but not by tetrodotoxin or morphine. The augmentation of the response to ACh by physostigmine was unaffected by hemicholinium. The phasic contraction of the tissue elicited by 30 mM KCl was also enhanced by methysergide, and this enhancement was prevented by the pre-addition of atropine (1.4 x 10(-7) M). In the depolarized vas deferens after exposure to 30 mM KCl, methysergide occasionally induced a sustained tonic contraction which was inhibited by atropine. These findings suggest that methysergide facilitates a release of ACh by acting on the cholinergic nerve terminals and selectively potentiates the cholinergic response.

References

Aug 1, 1980·British Journal of Clinical Pharmacology·P Turner

Citations

Oct 1, 1976·British Journal of Pharmacology·E ApperleyG P Levy
Mar 1, 1967·British Journal of Pharmacology and Chemotherapy·M D Gershon
Nov 1, 1968·The Journal of Pharmacy and Pharmacology·N B Thoa, G D Maengwyn-Davies
Feb 15, 1971·Life Sciences. Pt. 1: Physiology and Pharmacology·D W Gant, D C Dyer
Nov 24, 1956·Nature·R I BIRKSP B SASTRY
Sep 1, 1957·British Journal of Pharmacology and Chemotherapy·J H GADDUM, Z P PICARELLI
Feb 1, 1965·British Journal of Pharmacology and Chemotherapy·S HUKOVICS VANOV

Related Concepts

Histamine Measurement
KNG1
Arecoline
Cavia
Morphine Measurement
Atropine
Contraction (Finding)
Smooth Muscle
Tetrodotoxin
Atropinum, atropine

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