Meticillin-resistant Staphylococcus aureus infection in diabetic mice enhanced inflammation and coagulation

Journal of Medical Microbiology
Shyh-Ming TsaoMei-Chin Yin

Abstract

BALB/cA mice were used to study the interaction of diabetes and meticillin-resistant Staphylococcus aureus (MRSA) infection on pathogen distribution, cytokine profile and inflammatory and endothelial-injury markers, as well as coagulation and anticoagulation factors. Meticillin-susceptible S. aureus (MSSA) infection did not cause death within the experimental period. MRSA-infected nondiabetic and diabetic mice died on 19.1+/-1.4 and 10.6+/-0.7 days post-infection (p.i.), respectively. MRSA and MSSA infection in diabetic mice did not result in symptomatic bacteraemia; however, MRSA infection in diabetic mice significantly reduced glucose levels (P<0.05). Diabetic mice showed significantly higher levels of C-reactive protein, fibrinogen, fibronectin and von Willebrand factor than nondiabetic mice (P<0.05), and MRSA infection further elevated the plasma levels of these inflammatory and endothelial markers (P<0.05). Before infection, diabetic mice had significantly higher plasminogen activator inhibitor-1 (PAI-1) activity, lower antithrombin III (AT-III) and protein C activities (P<0.05), and MRSA infection significantly increased PAI-1 activity further and reduced the activity of AT-III and protein C (P<0.05). MRSA infection incre...Continue Reading

References

Apr 1, 1996·Journal of Autoimmunity·A ShimadaC G Fathman
Jul 1, 1997·The Journal of Antimicrobial Chemotherapy·K HiramatsuF C Tenover
Apr 3, 1998·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·K J MattilaS Asikainen
Aug 26, 1998·The New England Journal of Medicine·F D Lowy
Jan 9, 1999·The New England Journal of Medicine·S BlotF Colardyn
May 11, 2000·Seminars in Thrombosis and Hemostasis·T UranoA Takada
May 18, 2000·Scandinavian Cardiovascular Journal : SCJ·M Leinonen, P Saikku
Jul 23, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·K KainP J Grant
Sep 19, 2003·Pathophysiology of Haemostasis and Thrombosis·Irène Juhan-VagueMarie-Christine Alessi
Oct 4, 2003·Diabetes & Metabolism·M B GomesH J Matos
Oct 31, 2003·The Journal of Antimicrobial Chemotherapy·Shyh-ming TsaoMei-chin Yin

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Citations

Apr 1, 2010·Indian Journal of Clinical Biochemistry : IJCB·M BokaeianAzim Akbarzadeh
Apr 5, 2019·The Journal of Toxicological Sciences·Nana LongMin Dai
May 21, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Hong HeHai-Ying Gu
May 26, 2017·Frontiers in Cellular and Infection Microbiology·Markus BischoffRosmarie Gaupp
Feb 8, 2007·Journal of Clinical Apheresis·Christine M CsertiLynne Uhl

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