PMID: 43755Dec 1, 1979

Metoclopramide and haloperidol in tardive dyskinesia

The British Journal of Psychiatry : the Journal of Mental Science
D N BatemanM D Rawlins


The effect of single intravenous doses of metoclopramide (10 mg, 20 mg and 40 mg) and haloperidol (5 mg and 10 mg) have been compared to placebo (saline) in a double blind randomised study in 8 patients with tardive dyskinesia secondary to neuroleptic therapy. Tardive dyskinesia rating scores were improved significantly (P less than 0.01) 6 hours after dosing by metoclopramide 40 mg, and haloperidol 5 mg and 10 mg, when compared to placebo. Single doses of dopamine receptor blocking agents improve tardive dyskinesia. The dose of metochlopramide required to show a beneficial effect was high, and this therefore suggests that it is unlikely to be of therapeutic value as the incidence of adverse reactions would be greatly increased. By monitoring the effects of single doses of dopamine receptor blocking drugs in patients with tardive dyskinesia it is possible to compare the relative potencies of these drugs on dopaminergic systems in vivo in man.


Dec 9, 1978·Lancet·M KatariaC D Marsden
Jan 11, 1979·Nature·J W Kebabian, D B Calne
Apr 1, 1975·The Journal of Pharmacy and Pharmacology·M D Day, P R Blower
Jan 1, 1978·Annual Review of Pharmacology and Toxicology·L I GoldbergJ D Kohli
Oct 1, 1978·Clinical Pharmacology and Therapeutics·D N BatemanJ L Reid
Aug 1, 1979·British Journal of Clinical Pharmacology·D N BatemanD S Davies
Jan 14, 1978·British Medical Journal·S LavyS Penchas
Nov 1, 1978·British Journal of Clinical Pharmacology·D N BatemanD S Davies
Jan 1, 1973·The American Journal of Psychiatry·H L Klawans
Feb 1, 1970·Archives of Disease in Childhood·M Casteels-Van DaeleP Van den Bon


Jan 1, 1990·Movement Disorders : Official Journal of the Movement Disorder Society·L G Miller, J Jankovic
Jul 1, 1983·Brain Research Bulletin·G L WillisP C Kinchington
Sep 5, 1998·Brain Research. Brain Research Reviews·G L Willis, S M Armstrong
Jul 1, 1992·The International Journal of Neuroscience·G L WillisR Sandyk
Nov 19, 2013·The Cochrane Database of Systematic Reviews·Clive E AdamsStephen Lawrie
Jan 27, 2006·The Cochrane Database of Systematic Reviews·Karla Soares-Weiser, John Rathbone
Jan 27, 2006·The Cochrane Database of Systematic Reviews·Hany G El-SayehKarla Soares-Weiser
Jan 18, 2018·The Cochrane Database of Systematic Reviews·Hany G El-SayehHanna Bergman
Oct 1, 1985·Drug Intelligence & Clinical Pharmacy·A F Shaughnessy

Related Concepts

Dose-Response Relationship, Drug
Double-Blind Method
Dyskinesia, Medication-Induced
Dopamine Receptor
Antipsychotic Effect

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Synthetic Genetic Array Analysis

Synthetic genetic arrays allow the systematic examination of genetic interactions. Here is the latest research focusing on synthetic genetic arrays and their analyses.

Congenital Hyperinsulinism

Congenital hyperinsulinism is caused by genetic mutations resulting in excess insulin secretion from beta cells of the pancreas. Here is the latest research.

Neural Activity: Imaging

Imaging of neural activity in vivo has developed rapidly recently with the advancement of fluorescence microscopy, including new applications using miniaturized microscopes (miniscopes). This feed follows the progress in this growing field.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Epigenetic Memory

Epigenetic memory refers to the heritable genetic changes that are not explained by the DNA sequence. Find the latest research on epigenetic memory here.

Cell Atlas of the Human Eye

Constructing a cell atlas of the human eye will require transcriptomic and histologic analysis over the lifespan. This understanding will aid in the study of development and disease. Find the latest research pertaining to the Cell Atlas of the Human Eye here.

Femoral Neoplasms

Femoral Neoplasms are bone tumors that arise in the femur. Discover the latest research on femoral neoplasms here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Related Papers

European Archives of Psychiatry and Clinical Neuroscience
W F Gattaz, J Gerlach
Pharmacology & Therapeutics. Part B: General & Systematic Pharmacology
K F Gey, A Pletscher
© 2021 Meta ULC. All rights reserved