PMID: 43755Dec 1, 1979

Metoclopramide and haloperidol in tardive dyskinesia

The British Journal of Psychiatry : the Journal of Mental Science
D N BatemanM D Rawlins

Abstract

The effect of single intravenous doses of metoclopramide (10 mg, 20 mg and 40 mg) and haloperidol (5 mg and 10 mg) have been compared to placebo (saline) in a double blind randomised study in 8 patients with tardive dyskinesia secondary to neuroleptic therapy. Tardive dyskinesia rating scores were improved significantly (P less than 0.01) 6 hours after dosing by metoclopramide 40 mg, and haloperidol 5 mg and 10 mg, when compared to placebo. Single doses of dopamine receptor blocking agents improve tardive dyskinesia. The dose of metochlopramide required to show a beneficial effect was high, and this therefore suggests that it is unlikely to be of therapeutic value as the incidence of adverse reactions would be greatly increased. By monitoring the effects of single doses of dopamine receptor blocking drugs in patients with tardive dyskinesia it is possible to compare the relative potencies of these drugs on dopaminergic systems in vivo in man.

References

Dec 9, 1978·Lancet·M KatariaC D Marsden
Jan 11, 1979·Nature·J W Kebabian, D B Calne
Apr 1, 1975·The Journal of Pharmacy and Pharmacology·M D Day, P R Blower
Jan 1, 1978·Annual Review of Pharmacology and Toxicology·L I GoldbergJ D Kohli
Oct 1, 1978·Clinical Pharmacology and Therapeutics·D N BatemanJ L Reid
Aug 1, 1979·British Journal of Clinical Pharmacology·D N BatemanD S Davies
Jan 14, 1978·British Medical Journal·S LavyS Penchas
Nov 1, 1978·British Journal of Clinical Pharmacology·D N BatemanD S Davies
Jan 1, 1973·The American Journal of Psychiatry·H L Klawans
Feb 1, 1970·Archives of Disease in Childhood·M Casteels-Van DaeleP Van den Bon

Citations

Jan 1, 1990·Movement Disorders : Official Journal of the Movement Disorder Society·L G Miller, J Jankovic
Jul 1, 1983·Brain Research Bulletin·G L WillisP C Kinchington
Sep 5, 1998·Brain Research. Brain Research Reviews·G L Willis, S M Armstrong
Jul 1, 1992·The International Journal of Neuroscience·G L WillisR Sandyk
Nov 19, 2013·The Cochrane Database of Systematic Reviews·Clive E AdamsStephen Lawrie
Jan 27, 2006·The Cochrane Database of Systematic Reviews·Karla Soares-Weiser, John Rathbone
Jan 27, 2006·The Cochrane Database of Systematic Reviews·Hany G El-SayehKarla Soares-Weiser
Jan 18, 2018·The Cochrane Database of Systematic Reviews·Hany G El-SayehHanna Bergman
Oct 1, 1985·Drug Intelligence & Clinical Pharmacy·A F Shaughnessy

Related Concepts

Dose-Response Relationship, Drug
Double-Blind Method
Dyskinesia, Medication-Induced
Haldol
Rimetin
Dopamine Receptor
Antipsychotic Effect

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