PMID: 11907399Mar 22, 2002Paper

Metoclopramide-induced raised intracranial pressure after head injury

Journal of Neurosurgical Anesthesiology
Simon Deehan, Geoffrey J Dobb

Abstract

We report a case of raised intracranial pressure in a head-injured patient following the intravenous administration of metoclopramide. The patient required admission to an intensive care unit after a road traffic accident. A CT scan of the head was consistent with diffuse axonal injury and supportive management included intracranial pressure monitoring. On the third day after admission, intravenous metoclopramide 10mg was administered to aid gastric emptying during nasogastric feeding. Intracranial pressure increased to 39mmHg from a baseline of 15-20mmHg. The same dose of metoclopramide was repeated the next day during transcranial doppler studies with an increase in ICP to 34mmHg and an associated rise in middle cerebral artery systolic blood velocity from 122cms-1 to 150cms-1. This effect of metoclopramide has not been previously reported.

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Citations

Nov 13, 2002·Pharmacoepidemiology and Drug Safety
Nov 23, 2006·Intensive Care Medicine·Sonja FruhwaldHelfried Metzler
May 4, 2011·Current Gastroenterology Reports·Jinesh P MehtaMihir Kishorchandra Patel
Oct 5, 2006·Current Opinion in Anaesthesiology·Nicolas J Bruder
Mar 1, 2007·Current Opinion in Critical Care·Marianne J ChapmanRobert J L Fraser
Feb 13, 2015·Critical Care : the Official Journal of the Critical Care Forum·Y Gert van der MeerArthur R H van Zanten
Mar 22, 2015·International Journal of Obstetric Anesthesia·J A AnsonP M McQuillan
Nov 7, 2009·JPEN. Journal of Parenteral and Enteral Nutrition·Roland N DickersonRex O Brown
Oct 1, 2011·Therapeutic Advances in Drug Safety·Nam Q Nguyen, Swee Lin Chen Yi Mei

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