PMID: 697081Oct 1, 1978Paper

Metocurine in infants and children: neuromuscular and clinical effects

Anesthesiology
N G GoudsouzianJ J Savarese

Abstract

A cumulative dose--response curve for metocurine based on body weight was determined in 30 infants and children during halothane (1.2 per cent inspired), nitrous oxide and oxygen (60/40 per cent) anesthesia. The mean and range of twitch depression and time for recovery from maximal neuromuscular blockade were not significantly different over an age range from newborn to 7 years. Metocurine is twice as potent as d-tubocurarine in children, and their requirement is more than that for adults. The rate of recovery from metocurine in children was the same as that from d-tubocurarine. In another 30 children, use of metocurine at a large dose (0.5 mg/kg) for endotracheal intubation caused no significant change in blood pressure or pulse rate. Cardial arrhythmias were not seen.

Citations

May 1, 1984·Canadian Anaesthetists' Society Journal·C F Ward
May 1, 1984·Canadian Anaesthetists' Society Journal·N G GoudsouzianH H Ali
May 1, 1984·Canadian Anaesthetists' Society Journal·F DonatiD R Bevan
May 1, 1985·Canadian Anaesthetists' Society Journal·N G Goudsouzian
May 1, 1986·Canadian Anaesthetists' Society Journal·D R Cook

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