Metoprolol improves cardiac function and modulates cardiac metabolism in the streptozotocin-diabetic rat

American Journal of Physiology. Heart and Circulatory Physiology
Vijay SharmaJohn H McNeill

Abstract

The effects of diabetes on heart function may be initiated or compounded by the exaggerated reliance of the diabetic heart on fatty acids and ketones as metabolic fuels. beta-Blocking agents such as metoprolol have been proposed to inhibit fatty acid oxidation. We hypothesized that metoprolol would improve cardiac function by inhibiting fatty acid oxidation and promoting a compensatory increase in glucose utilization. We measured ex vivo cardiac function and substrate utilization after chronic metoprolol treatment and acute metoprolol perfusion. Chronic metoprolol treatment attenuated the development of cardiac dysfunction in streptozotocin (STZ)-diabetic rats. After chronic treatment with metoprolol, palmitate oxidation was increased in control hearts but decreased in diabetic hearts without affecting myocardial energetics. Acute treatment with metoprolol during heart perfusions led to reduced rates of palmitate oxidation, stimulation of glucose oxidation, and increased tissue ATP levels. Metoprolol lowered malonyl-CoA levels in control hearts only, but no changes in acetyl-CoA carboxylase phosphorylation or AMP-activated protein kinase activity were observed. Both acute metoprolol perfusion and chronic in vivo metoprolol trea...Continue Reading

References

Aug 1, 1991·The New England Journal of Medicine·UNKNOWN SOLVD InvestigatorsJay N Cohn
Nov 1, 1969·The Journal of Clinical Investigation·A JunodA E Renold
Jul 1, 1982·Canadian Journal of Physiology and Pharmacology·R V VadlamudiJ H McNeill
Aug 1, 1994·The American Journal of Physiology·M F AllardG D Lopaschuk
Jan 1, 1996·EXS·M F Allard, G D Lopaschuk
Aug 4, 1999·Journal of Diabetes and Its Complications·J I MaloneE Gilbert-Barness
Mar 11, 2000·American Journal of Physiology. Endocrinology and Metabolism·R BuettnerR M O'Doherty
Aug 19, 2000·American Journal of Physiology. Endocrinology and Metabolism·M F AllardG P Bondy
Jul 24, 2001·American Journal of Hypertension·S VermaJ H McNeill
Mar 30, 2002·Cardiovascular Research·Carmen P LydellMichael F Allard
May 3, 2002·The New England Journal of Medicine·Brian D LowesMichael R Bristow
May 4, 2002·Heart Failure Reviews·William C Stanley, Margaret P Chandler
Oct 24, 2002·Journal of Molecular and Cellular Cardiology·Jason R B Dyck, Gary D Lopaschuk
May 1, 1960·The Journal of Clinical Investigation·F B BALLARDR J BING
Nov 8, 2003·Nutrition Reviews·Theodore B VanItallie, Thomas H Nufert
Nov 15, 2003·Circulation Research·Martin J LohseThomas Eschenhagen
Feb 24, 2004·Molecular and Cellular Biochemistry·V A SaksE K Seppet
Nov 6, 2004·Current Hypertension Reports·Darrell D Belke, Wolfgang H Dillmann
May 21, 2005·Biochimica Et Biophysica Acta·Andrew N Carley, David L Severson
Jul 5, 2005·Journal of the American College of Cardiology·Muthayyah SrinivasanRobert J Gropler
Aug 22, 2006·American Journal of Physiology. Heart and Circulatory Physiology·Michael F AllardRoger Brownsey
Dec 2, 2006·Cardiovascular Drugs and Therapy·Hye-Lim NohIra J Goldberg
Dec 26, 2006·Journal of Molecular and Cellular Cardiology·Girish KewalramaniBrian Rodrigues

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Citations

Dec 1, 2011·Journal of Bioenergetics and Biomembranes·Erkan TuncayBelma Turan
Jul 30, 2010·Cardiovascular Research·Mariana G Rosca, Charles L Hoppel
Dec 9, 2008·American Journal of Physiology. Heart and Circulatory Physiology·Aaron P KelloggRodica Pop-Busui
Jan 25, 2011·American Journal of Physiology. Heart and Circulatory Physiology·Benjamin LauzierChristine Des Rosiers
Dec 16, 2010·Analytical Sciences : the International Journal of the Japan Society for Analytical Chemistry·Liangcai ZhaoDonghai Lin
Mar 29, 2012·Vascular Health and Risk Management·Jorge Eduardo ToblliFernando Pablo Dominici
Sep 18, 2014·Canadian Journal of Physiology and Pharmacology·Varun SaranJohn Hugh McNeill
Apr 25, 2012·Canadian Journal of Physiology and Pharmacology·Arzu Onay-BesikciA Tanju Ozcelikay
Jan 31, 2016·Biochimica Et Biophysica Acta·Xavier PalomerManuel Vázquez-Carrera
Mar 10, 2010·Trends in Cardiovascular Medicine·Stephen C Kolwicz, Rong Tian
Oct 18, 2015·Biochimie·Timothy M GriffinLuke I Szweda
Oct 30, 2012·International Immunopharmacology·Silvia ReinaEnri Borda
Sep 5, 2009·American Journal of Hypertension·R Preston MasonTadeusz Malinski
Oct 15, 2010·Free Radical Research·Janos KernerCharles L Hoppel
Sep 25, 2017·The Journal of Pharmacology and Experimental Therapeutics·Natalie E Scholpa, Rick G Schnellmann
Aug 9, 2016·American Journal of Physiology. Heart and Circulatory Physiology·Fanny VaillantChristine Des Rosiers
Jun 11, 2009·British Journal of Pharmacology·Vijay Sharma, John H McNeill
Oct 8, 2017·American Journal of Physiology. Heart and Circulatory Physiology·Quincy A HathawayJohn M Hollander
Jan 6, 2021·Cardiovascular Diabetology·Lin WangZhengyuan Xia
May 1, 2021·International Journal of Molecular Sciences·Xiaonan SunHongyu Qiu
Jun 3, 2021·International Journal of Molecular Sciences·Dianne M Perez

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