Metoprolol in the treatment of cardiovascular disease: a critical reappraisal

Current Medical Research and Opinion
Guido Grassi

Abstract

Extensive clinical experience on metoprolol has been gained in different cardiovascular conditions. This paper discusses the use of metoprolol, with a focus on the extended-release formulation, in clinical practice in the light of existing evidence and current recommendations. This is a narrative review based on existing evidence and clinical experience of the author. Evidence on the use of metoprolol in heart failure, ischemic artery disease, arterial hypertension, and atrial fibrillation is well-established. Metoprolol still appears to be a suitable pharmacological option in different cardiovascular conditions. Research on this molecule is still active and new, promising settings of use are being explored and may provide relevant results in the years to come.

References

May 22, 1990·The American Journal of Cardiology·J N Cohn
Nov 1, 1993·American Heart Journal·A SigurdssonK Swedberg
Feb 28, 2002·Journal of Cardiac Failure·Johan HerlitzUNKNOWN MERIT--HF Study Group
Oct 18, 2003·American Heart Journal·András JánosiUNKNOWN MERIT-HF Study Group
Aug 4, 2004·European Heart Journal·Prakash C DeedwaniaUNKNOWN MERIT-HF Study Group
Apr 22, 2005·The American Journal of Cardiology·Philip GreenThierry H Le Jemtel
Nov 8, 2005·Lancet·Z M ChenUNKNOWN COMMIT (ClOpidogrel and Metoprolol in Myocardial Infarction Trial) collaborative group
Mar 29, 2006·European Journal of Heart Failure·Dirk J van VeldhuisenUNKNOWN MERIT-HF Study Group
May 12, 2006·The Journal of Clinical Hypertension·Bonita FalknerHarvey Kushner
Jan 6, 2009·The American Journal of Cardiology·Xavier JouvenPierre Ducimetière
Dec 16, 2010·Journal of Hypertension·Giovanni CorraoGiuseppe Mancia
Nov 2, 2011·Nihon Rinshō Men'eki Gakkai kaishi = Japanese journal of clinical immunology·Kiyoshi Migita, Kazunaga Agematsu
Feb 22, 2013·Journal of Cardiovascular Pharmacology and Therapeutics·Pawel PtaszynskiJerzy K Wranicz
Mar 8, 2013·Heart, Lung & Circulation·Marina A SkibaFranklin L Rosenfeldt
Apr 2, 2014·The Annals of Pharmacotherapy·Toni L Ripley, Joseph J Saseen
Dec 30, 2014·Cardiovascular & Hematological Agents in Medicinal Chemistry·Emanuela FacchiniAngelo S Bongo
Apr 29, 2015·International Journal of Cardiology·Björn PasternakAnders Hviid
Nov 4, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Alessandro CapucciFederico Guerra
Aug 28, 2016·European Heart Journal·Paulus KirchhofUNKNOWN ESC Scientific Document Group
Dec 14, 2016·Advances in Experimental Medicine and Biology·John M Cruickshank
Mar 31, 2017·American Journal of Cardiovascular Drugs : Drugs, Devices, and Other Interventions·Csaba András Dézsi, Veronika Szentes

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Citations

Jun 10, 2020·Kardiologiia·O N TkachevaK A Eruslanova

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