Metoprolol prevents sodium retention induced by lower body negative pressure in healthy men

Kidney International
Gregoire WuerznerMichel Burnier

Abstract

Lower body negative pressure (LBNP) has been shown to induce a progressive activation of neurohormonal systems, and a renal tubular and hemodynamic response that mimics the renal adaptation observed in congestive heart failure (CHF). As beta-blockers play an important role in the management of CHF patients, the effects of metoprolol on the renal response were examined in healthy subjects during sustained LBNP. Twenty healthy male subjects were randomized in this double blind, placebo versus metoprolol 200 mg once daily, study. After 10 days of treatment, each subject was exposed to 3 levels of LBNP (0, -10, and -20 mbar) for 1 hour, each level of LBNP being separated by 2 days. Neurohormonal profiles, systemic and renal hemodynamics, as well as renal sodium handling were measured before, during, and after LBNP. Blood pressure and heart rate were significantly lower in the metoprolol group throughout the study (P < 0.01). GFR and RPF were similar in both groups at baseline, and no change in renal hemodynamic values was detected at any level of LBNP. However, a reduction in sodium excretion was observed in the placebo group at -20 mbar, whereas no change was detected in the metoprolol group. An increase in plasma renin activity w...Continue Reading

References

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Citations

Jul 8, 2009·Pakistan Journal of Biological Sciences : PJBS·F R Ghader, Z A Abaskhanian
Apr 8, 2006·Journal of Hypertension. Supplement : Official Journal of the International Society of Hypertension·Gregoire Wuerzner, Michel Burnier
Nov 6, 2018·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·René van der BelC T Paul Krediet
Dec 17, 2008·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Simon MølstrømPeter Bie

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