PMID: 7547016Sep 1, 1995Paper

Metoprolol treatment for two years after coronary bypass grafting: effects on exercise capacity and signs of myocardial ischaemia

British Heart Journal
H SjölandJ Herlitz

Abstract

To evaluate whether prophylactic treatment with metoprolol for two years after coronary artery bypass grafting improves working capacity and reduces the occurrence of myocardial ischaemia in patients with coronary artery disease. After coronary artery bypass grafting, patients were randomised to treatment with metoprolol or placebo for two years. Two years after randomisation, a computerised 12-lead electrocardiogram was obtained during a standardised bicycle exercise test in 618 patients (64% of all those randomised). The median exercise capacity was 140 W in the metoprolol group (n = 307) and 130 W in the placebo group (n = 311) (P > 0.20). An ST depression of > or = 1 mm at maximum exercise was present in 34% of the patients in the metoprolol group and 38% in the placebo group (P > 0.20) and an ST depression of > or = 2 mm at maximum exercise was present in 11% in the metoprolol group and 16% in the placebo group (P = 0.09). The median values for maximum systolic blood pressure were 200 mm Hg in the metoprolol group and 210 mm Hg in the placebo group (P < 0.0001), while the median values for maximum heart rate were 126 beats/min in the metoprolol group and 143 beats/min in the placebo group (P < 0.0001). The occurrence of ca...Continue Reading

References

Oct 1, 1991·Journal of the American College of Cardiology·B AnderssonF Waagstein
Mar 1, 1989·The American Journal of Cardiology·P DubachR Detrano
Apr 14, 1989·JAMA : the Journal of the American Medical Association·R M CaliffD B Pryor
Nov 1, 1987·The American Journal of Cardiology·P A AdesJ LaMountain
Feb 1, 1987·IEEE Transactions on Bio-medical Engineering·O Pahlm, L Sörnmo
Jan 1, 1982·Medicine and Science in Sports and Exercise·G A Borg
Jan 1, 1993·International Journal of Cardiac Imaging·F C VisserP J de Feyter

❮ Previous
Next ❯

Citations

Oct 2, 1998·Clinical Cardiology·W S HirschM N Kotler
Sep 22, 2010·The American Journal of Cardiology·Michael FrankMarc Laskar
Jan 18, 2005·Journal of the American College of Cardiology·Karen OkrainecMark J Eisenberg
May 27, 2016·Nature Reviews. Cardiology·Roberto Ferrari, Kim Fox
Oct 18, 2016·Current Opinion in Cardiology·Alexander Kulik
Oct 14, 2017·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Miguel Sousa-UvaUlf Landmesser
Feb 14, 2015·Circulation·Alexander KulikUNKNOWN American Heart Association Council on Cardiovascular Surgery and Anesthesia

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.