Metrifonate for Alzheimer's disease

The Cochrane Database of Systematic Reviews
J M López-Arrieta, L Schneider

Abstract

Metrifonate is a long-acting irreversible cholinesterase inhibitor, originally used to treat schistosomiasis. Its potential to enhance central nervous system cholinergic neurotransmission led to clinical trials for the treatment of people with Alzheimer's disease (AD). Although low incidence of serious side effects occurred during short-term use as an antihelmintic, in studies of the treatment of AD extending over 6 months, 20 patients experienced respiratory paralysis and problems with neuromuscular transmission. These findings have led to a halt to trials of metrifonate for AD and Bayer, the pharmaceutical company, has withdrawn its FDA application. 1) To establish the efficacy of metrifonate for patients with Alzheimer's disease, in terms of cognition, global impression, functional activity, non cognitive symptoms, rate of institutionalization and mortality.2) Assess the safety and tolerability of metrifonate. The Cochrane Dementia and Cognitive Improvement Group's Specialized Register was searched on 5 December 2005 using the term metrifonat*. This Register is regularly updated with records from all major health care databases (MEDLINE, EMBASE, CINAHL, PsycINFO) and many trials databases. One of the authors (LS), as member ...Continue Reading

References

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Apr 21, 2006·The Cochrane Database of Systematic Reviews·J M López-Arrieta, L Schneider

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Citations

Nov 9, 2010·International Journal for Parasitology·Maha M EissaNahed M Baddour
May 1, 2009·Therapeutic Advances in Neurological Disorders·Krista L LanctôtNathan Herrmann
Apr 21, 2006·The Cochrane Database of Systematic Reviews·J M López-Arrieta, L Schneider
Apr 12, 2007·Expert Review of Neurotherapeutics·Kevin R Scott, Anna M Barrett
Jul 1, 2009·Der Nervenarzt·H Förstl
Jun 4, 2014·International Journal of Molecular Sciences·Miroslav Pohanka
Aug 20, 2015·The Journal of Parasitology·Flaviano Benavides-GonzálezIsidro Otoniel Montelongo-Alfaro
Aug 19, 2007·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Betul Karademir CatalgolBuket Alpertunga

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