Abstract
We studied physical fitness, as determined by the Harvard Step Test (HST), and appetite, as measured by the consumption of a morning snack (maize meal porridge), in primary school boys infected with Schistosoma haematobium (100% baseline prevalence) and hookworm (94-100% prevalence) who received a single dose of metrifonate (MT, 10 mg/kg body weight) or praziquantel (PR, 40 mg/kg body weight), or a placebo (PL). Five weeks after treatment, HST scores and porridge intake increased significantly in the MT and PR groups, but the PL group did not change. At the second examination, the MT group showed a significant decrease in S. haematobium egg counts (mean = 180 vs. 14 eggs/10 ml adj, P less than 0.0002, 82% egg reduction in arithmetic means) as did the PR group (mean = 198 vs. 0.1 eggs/10 ml adj, P less than 0.0002, 99.9% reduction); the egg counts in the PL group did not change. The MT group also exhibited a significant decrease in hookworm egg counts (mean = 1,550 vs. 75 eggs per gram feces [epg], P less than 0.0005, 80% reduction). Treatment with either drug may allow improved physical fitness and appetite in areas where S. haematobium and protein-energy malnutrition are highly prevalent.
Citations
Nov 1, 1996·Parasitology·V HadjuR S Parker
Nov 14, 1997·The Journal of Nutrition·R J StoltzfusL Savioli
Nov 11, 1998·Tropical Medicine & International Health : TM & IH·O C NwaorguD Evans
Mar 20, 2008·Maternal & Child Nutrition·Andrew HallNilanthi de Silva
Apr 27, 2012·BMC Medicine·Andrew HallShawn Baker
Oct 4, 2014·Clinical Microbiology Reviews·Tim K MackeyDaniel E Lee
Mar 2, 2017·Parasitology·Amaya L BustinduyJ Russell Stothard
Jan 28, 2017·Parasites & Vectors·Julien Zwang, Piero Olliaro
Jun 1, 1997·The Journal of Nutrition·R J StoltzfusL Savioli
Jan 1, 1993·Parasitology·L Stephenson
May 2, 1996·The New England Journal of Medicine·L X Liu, P F Weller
Aug 12, 2004·Tropical Medicine & International Health : TM & IH·K M BosompemN Ohta
Jul 18, 2017·Journal of Environmental and Public Health·Justice AfrifaIsaac Mensah-Essilfie
Feb 7, 2018·Bulletin of the World Health Organization·Jennifer F FriedmanAlison M Elliott
Mar 1, 1990·Transactions of the Royal Society of Tropical Medicine and Hygiene·L S StephensonH Brigham
Aug 22, 2001·Paediatric Drugs·L S Stephenson
Nov 22, 2018·Advances in Nutrition·Scott B IckesDonna M Denno
Sep 12, 2019·The Cochrane Database of Systematic Reviews·David C Taylor-RobinsonPaul Garner
May 1, 1992·Transactions of the Royal Society of Tropical Medicine and Hygiene·E L CorbettR F Sturrock
Oct 23, 2004·Arquivos De Gastroenterologia·Luiz Eduardo Correia MirandaHélio Vannucchi
Nov 21, 2014·PLoS Neglected Tropical Diseases·Julien Zwang, Piero L Olliaro
Jul 14, 2011·PLoS Neglected Tropical Diseases·Amaya L BustinduyCharles H King
Jul 24, 2015·The Cochrane Database of Systematic Reviews·David C Taylor-RobinsonPaul Garner
Aug 8, 2014·The Cochrane Database of Systematic Reviews·Christine V KramerPiero L Olliaro
Apr 15, 2016·PLoS Neglected Tropical Diseases·David C Geary
Jan 1, 2007·Human Ecology: an Interdisciplinary Journal·D PimentelC Weinstein
Jan 1, 1996·European Journal of Applied Physiology and Occupational Physiology·R de JongeJ Coudert
May 6, 2003·The Journal of Nutrition·Richard W Steketee
May 18, 1999·Transactions of the Royal Society of Tropical Medicine and Hygiene·A OlsenH Friis
Mar 7, 2008·Chronic Illness·Charles H King, Madeline Dangerfield-Cha