PMID: 2126114Dec 1, 1990Paper

Metronidazole in head and neck surgery--the effect of lengthened prophylaxis

Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery
R SawyerA J Maniglia

Abstract

Previous studies of antibiotic prophylaxis have shown that treatment for 24 hours has been beneficial for head and neck surgery and that longer periods of antibiotic therapy have not improved results. Metronidazole (Flagyl), unlike other antibiotics tested, has been shown to be effective in an experimental abscess, even if treatment is begun up to 120 hours after administration of inoculum. This article presents a prospective, randomized, multifactorial study comparing a brief vs. a prolonged duration of metronidazole and cefazolin prophylaxis in 50 consecutive patients with a head and neck cancer undergoing operation. Patients receiving 2 days vs. 7 or more days of antibiotic prophylaxis were compared. Statistical analysis of data demonstrated a striking reduction in severity of wound complications and a reduced incidence of wound infections in the group treated with 7 or more days of antibiotic prophylaxis.

References

Dec 1, 1986·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·J T JohnsonR L Wagner
Aug 1, 1988·The Laryngoscope·K T RobbinsH Goepfert
Jul 1, 1983·The Annals of Otology, Rhinology, and Laryngology·R K NewmanL W Gumerman
Feb 1, 1980·The Surgical Clinics of North America·P J Cruse, R Foord

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Citations

Jul 1, 1997·The Journal of Laryngology and Otology·M StraussA L Allphin
Feb 7, 2018·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Priyesh N PatelDavid O Francis
Jul 12, 2017·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Peter M VilaRyan S Jackson

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