PMID: 8450081Mar 1, 1993Paper

Metronidazole in the treatment of localized juvenile periodontitis

Journal of Clinical Periodontology
L Saxén, S Asikainen

Abstract

Systemic metronidazole and tetracycline were compared as adjunctive agents in the treatment of localized juvenile periodontitis (LJP). 27 patients with Actinobacillus actinomycetemcomitans-positive (Aa) LJP were treated with scaling and rootplaning, control of oral hygiene and periodontal surgery if indicated. The patients were randomly divided into 3 equal groups: the 1st group had metronidazole 200 mg x 3 x 10 days, the 2nd tetracycline 250 mg x 4 x 12 days, the 3rd group received no medication and served as a control. 6 patients had periodontal surgery. 4 sites with the most advanced bone loss as determined on radiographs were selected in each subject for test sites. Gingival index, gingival bleeding after probing (GB), probing depth (PD), suppuration, and radiographic bone loss were registered, and subgingival Aa was selectively cultured. GB and PD > or = 4 mm were registered in the whole dentition as well. All parameters were monitored at baseline and at 6 and 18 months after treatment. By the end of the study, Aa was suppressed to below detection level at all test sites only in the metronidazole group, at 17/26 sites (4 patients) in the tetracycline group and at 19/26 sites (6 patients) in the control group. Clinically, a...Continue Reading

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Citations

Oct 1, 1994·Journal of Clinical Periodontology·G A Van der WeijdenU Van der Velden
Jan 27, 1998·Journal of Clinical Periodontology·B von Troil-LindénS Asikainen
May 30, 1998·Journal of Clinical Periodontology·A J SmithT W MacFarlane
Oct 1, 1993·Scandinavian Journal of Dental Research·R PajukantaH Jousimies-Somer
Jun 1, 1994·Periodontology 2000·S S Socransky, A D Haffajee
Jun 1, 1994·Periodontology 2000·A D Haffajee, S S Socransky
Jun 1, 1994·Periodontology 2000·J M Goodson
Feb 1, 1996·Periodontology 2000·A J van WinkelhoffJ Slots
Oct 5, 2001·Clinical Microbiology Reviews·W J Loesche, N S Grossman
Nov 1, 1996·Annals of Periodontology·C H Drisko
Nov 1, 1996·Annals of Periodontology·K G Palcanis
Nov 1, 1996·Annals of Periodontology·J J Zambon
Jun 15, 1999·Journal of Periodontology·M H SaarelaS Asikainen
Nov 6, 2002·Journal of Periodontology·Clay Walker, Katherine Karpinia
Dec 20, 2003·Journal of Periodontology·Joseph V Califano, UNKNOWN Research, Science and Therapy Committee American Academy of Periodontology
Jan 7, 2005·Journal of Periodontology·Jørgen Slots, UNKNOWN Research, Science and Therapy Committee
May 15, 2013·Journal of Oral Microbiology·Orit Oettinger-BarakEric C Reynolds
Jun 29, 2002·Journal of Clinical Periodontology·Sebastian G Ciancio
Jun 15, 2007·Infectious Disease Clinics of North America·Walter Loesche
Apr 24, 2004·Australian Dental Journal·M KawamuraT Hamada
Mar 10, 2004·International Dental Journal·Andrea Mombelli, Lakshman P Samaranayake
Jul 18, 2008·Journal of Clinical Periodontology·Alex N HaasCassiano K Rösing
Mar 24, 2006·Journal of Clinical Periodontology·Christiana XajigeorgiouAntonis Konstantinidis
Sep 9, 2008·Journal of Clinical Periodontology·David HerreraMariano Sanz
Apr 21, 2010·Periodontology 2000·David E Deas, Brian L Mealey
Apr 18, 2014·Periodontology 2000·Wim TeughelsMarc Quirynen

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