Metronidazole in treatment against Haemophilus vaginalis (Corynebacterium vaginale).

Antimicrobial Agents and Chemotherapy
E D Ralph, Y E Amatnieks

Abstract

The rate of bactericidal activity and inactivation of metronidazole was studied in time-kill curves with Haemophilus vaginalis (Corynebacterium vaginale). The minimum inhibitory concentrations of metronidazole for the eight strains tested ranged from 4 to 16 micrograms/ml. At a concentration of 20 micrograms/ml, metronidazole demonstrated a slow cidal effect against exponential-phase organisms, requiring 24 to 48 h for completion. Inactivation of metronidazole during the time-kill curve was quite variable and averaged 28% of the starting concentration after 48 h. Against stationary-phase organisms (inoculum, 10(10) to 10(11) colony-forming units per ml), a slow cidal effect was also seen, with an average inactivation of metronidazole of 38% after 48 h. At a subinhibitory concentration of 5 micrograms/ml, metronidazole was inactivated to the greatest degree (57% after 48 h). Therefore, in contrast to earlier studies in which metronidazole was rapidly and consistently cidal within 4 h against obligate anaerobes and was almost completely inactivated by 8 h, the bactericidal effect of metronidazole againsts H. vaginalis in this study was much slower and was associated with a variable and slower rate of inactivation.

References

Mar 1, 1978·Antimicrobial Agents and Chemotherapy·F P TallyS L Gorbach
Jun 29, 1978·The New England Journal of Medicine·T A PheiferK K Holmes
Apr 1, 1977·Sexually Transmitted Diseases·W E Dunkelberg
Sep 1, 1978·Antimicrobial Agents and Chemotherapy·E D Ralph, D A Clarke
Jan 1, 1977·Sexually Transmitted Diseases·R F Smith, W E Dunkelberg
Jun 1, 1976·The Journal of Antimicrobial Chemotherapy·C W Plant, D I Edwards
Nov 1, 1975·The Journal of Infectious Diseases·E D Ralph, W M Kirby
May 1, 1974·Biochemical Pharmacology·R M IngsW E Ormerod

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Citations

Oct 1, 1982·European Journal of Clinical Microbiology·S ShankerR Munro
Jun 1, 1983·Journal of Adolescent Health Care : Official Publication of the Society for Adolescent Medicine·W L MinkowskiB Schultz
Oct 1, 1986·Infection Control : IC·M Eggleston

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