Metronidazole-induced reversible cerebellar lesions and peripheral neuropathy

Médecine et maladies infectieuses
S ToumiC Laouani-Kechrid

Abstract

Metronidazole is a widely prescribed treatment for amoebic and anaerobic germ infections. Its neurologic toxicity is rare but can be serious. We report the case of a 27-year-old male patient, treated with metronidazole for a cerebral abscess. He presented with a cerebellar syndrome and peripheral neuropathy at a cumulative metronidazole dose of 60g. The MRI aspect of the cerebellar lesions in addition to their reversibility after treatment cessation led to the diagnosis of metronidazole induced neurologic toxicity. The occurrence of neurologic disorders in patients treated with metronidazole must suggest drug toxicity and lead to cessation of treatment.

References

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Sep 29, 2004·Journal of the Neurological Sciences·Dong Wook KimSangYun Kim

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Citations

Sep 16, 2009·CMAJ : Canadian Medical Association Journal = Journal De L'Association Medicale Canadienne·Justyna R SarnaSarah Furtado
Nov 22, 2013·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Justyna R SarnaA Keith W Brownell

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