Metronidazole-Loaded Polyethyleneimine and Chitosan-Based Liquid Crystalline System for Treatment of Staphylococcal Skin Infections

Journal of Biomedical Nanotechnology
Francesca Damiani VictorelliMarlus Chorilli

Abstract

Staphylococcus aureus is a common gram-positive bacterium of the human skin microbiota. It is also a dangerous pathogen that can cause serious and even lethal skin infections. The topical administration of metronidazole via nanotechnology-based drug delivery systems, such as liquid crystalline systems, can modulate both the drug permeation and activity, decreasing its side effects and increasing the drug potent activity against the gram-positive bacteria. This study aimed at: (1) structurally developing and characterizing a liquid crystalline systems composed of chitosan and polyethyleneimine dispersion as the aqueous phase, oleic acid as the oily phase, and ethoxylated and propoxylated cetyl alcohol as the surfactant (FPC) for metronidazole incorporation (0.5% w/w); (2) evaluating the in vitro release and skin permeation and retention properties of the metronidazole-loaded liquid crystalline systems (FPC-M); (3) investigating the in vitro antibacterial activity of FPC-M against Staphylococcus aureus. Polarised light microscopy indicated that both FPC and FPC-M are hexagonal systems. Rheological, texture, and bioadhesion assays showed that both are elastic and bioadhesive systems. According to the results of the in vitro releas...Continue Reading

Citations

Jul 17, 2019·AAPS PharmSciTech·Giovana Maria Fioramonti CalixtoCarla Raquel Fontana
Sep 5, 2020·Expert Opinion on Drug Delivery·Ana Vitoria Pupo SilvestriniMaria Vitoria Lopes Badra Bentley
Dec 15, 2020·Biomedical Chromatography : BMC·Márcia Helena OyafusoMarlus Chorilli
Jul 19, 2019·Fitoterapia·Damaris Silva Dos SantosAdriana Gibara Guimarães
Mar 27, 2021·Carbohydrate Polymers·Victor Hugo Sousa AraujoMarlus Chorilli

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