Metronidazole pharmacokinetics during rapid growth in turkeys - relation to changes in haemodynamics and drug metabolism

Journal of Veterinary Pharmacology and Therapeutics
M ŚwitałaKamila Bobrek

Abstract

Whereas interspecies variation in pharmacokinetics is a commonly investigated issue, variations in drug kinetics within a species are less documented. The aim of the study was to assess the influence of age-related changes in haemodynamics on the pharmacokinetics of metronidazole (MTZ) and its hydroxy metabolite (MTZ-OH) in turkeys. MTZ was administered intravenously and orally at a dose of 25 mg/kg. Plasma drug and metabolite concentrations were assessed by high-performance liquid chromatography, and pharmacokinetic parameters were calculated by noncompartmental analysis. Haemodynamic parameters (heart rate, stroke volume, cardiac output) were assessed by echocardiography and extraction ratio for MTZ was calculated based on total body clearance (ClB ). Between the 5th and 15th week of age, ClB of MTZ decreased from 3.6 to 1.2 mL/min/kg causing a twofold increase in the mean residence time (MRT) and elimination half-life (T1/2el ). The MTZ-OH production decreased threefold and its MRT and T1/2el increased. Although heart rate significantly decreased with age, cardiac output increased. Extraction ratio was low in all age groups. It is concluded that significant age-dependent decrease in ClB of MTZ in turkeys resulted from decrea...Continue Reading

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Citations

Jul 1, 2017·Journal of Veterinary Pharmacology and Therapeutics·B PoźniakM Świtała
Dec 18, 2019·Journal of Veterinary Pharmacology and Therapeutics·Błażej PoźniakMarcin Świtała
Jun 2, 2020·Journal of Veterinary Science·Błażej PoźniakMarcin Świtała
Dec 12, 2020·EFSA Journal·UNKNOWN EFSA Panel on Biological Hazards (BIOHAZ)Friederike Hilbert
Apr 30, 2017·Research in Veterinary Science·Tomasz GrabowskiMarcin Świtała
Aug 4, 2021·Parasitology Research·Mohaddeseh Abouhosseini TabariMohammad Reza Youssefi

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