PMID: 2891754Nov 1, 1987Paper

Metronidazole prophylaxis in acute mural appendicitis: failure of a single intra-operative infusion to reduce wound infection

The Journal of Hospital Infection
M E AhmedM A Hassan

Abstract

The efficacy of a single 500 mg intravenous intra-operative dose of metronidazole in the prevention of postoperative wound infection, following appendicectomy for acute mural appendicitis, was studied in a prospective randomized placebo controlled trial. Fourteen of the 96 patients (14.6%) in the metronidazole group and 13 of the 94 in the placebo group (13.8%) developed postoperative wound infection. Late sepsis was noted in 4 out of the 96 patients in the metronidazole group and in one of the 94 patients in the placebo group. This study suggests that a single intra-operative dose of metronidazole dose not reduce the incidence of postoperative wound infection following appendicectomy for acute mural appendicitis.

References

Jul 1, 1985·The British Journal of Surgery·J DrummP Lowe
Dec 1, 1974·Journal of Clinical Pathology·D A LeighE Norman
Jun 1, 1974·The British Journal of Surgery·T BatesG J Lloyd
Nov 1, 2007·East African Medical Journal·M ElRashiedM E Ahmed

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Citations

Mar 7, 2013·Surgical Infections·Dale W BratzlerUNKNOWN Society for Healthcare Epidemiology of America (SHEA)
Jul 22, 2005·The Cochrane Database of Systematic Reviews·B R AndersenH K Andersen

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