PMID: 3487729May 1, 1986Paper

Metronidazole-resistant clinical isolates of Trichomonas vaginalis have lowered oxygen affinities

Molecular and Biochemical Parasitology
N YarlettD Lloyd

Abstract

Oxygen affinities of metronidazole susceptible and resistant isolates of the parasitic flagellate protozoon Trichomonas vaginalis were determined by mass spectrometric methods. Apparent O2Km values for the respiration of non-proliferating cell suspensions were about 10-fold higher for metronidazole resistant strains than for the susceptible strains C1-NIH or NYH-286. Simultaneous monitoring of hydrogen evolution in the presence of increasing O2 tensions enabled apparent Ki values for H2 to be determined; and this function was independent of metronidazole susceptibility. Apparent O2 affinities of the hydrogenosomal and non-sedimentable fractions were determined for the strains CDC 85 (metronidazole resistant) and C1-NIH, which showed the deficiency in the O2 scavenging capacity by the resistant strain to be associated with the hydrogenosome-containing fraction.

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Citations

Feb 1, 1987·International Journal for Parasitology·G H Coombs
Feb 1, 1993·International Journal for Parasitology·J E EllisD Lloyd
Jan 1, 1990·European Journal of Obstetrics, Gynecology, and Reproductive Biology·R M van der WeidenA M Polderman
Jun 1, 1990·Molecular and Biochemical Parasitology·Timothy Paget, D Lloyd
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Dec 19, 2000·Journal of Applied Microbiology·N A TurnerD Lloyd
May 1, 1993·The Journal of Eukaryotic Microbiology·Timothy PagetEdward L Jarroll
May 1, 1993·The Journal of Eukaryotic Microbiology·Jaroslav KuldaA Cerkasovová
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Jun 22, 2017·Genome Biology and Evolution·Martina BradicJane M Carlton
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Feb 27, 2016·F1000Research·David Leitsch
Nov 22, 2013·Molecular Microbiology·David LeitschMichael Duchêne
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May 11, 2004·Microbiology·Timothy PagetD Lloyd
May 8, 2021·International Journal for Parasitology. Drugs and Drug Resistance·Virág GehlDavid Leitsch

Related Concepts

Drug Resistance
Bayer 5360
Oxygen Consumption
Trichomonas vaginalis

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