Metronidazole toxicity presenting with acute onset of aphasia and right sided weakness

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia
Stacie L DemelAshutosh P Jadhav

Abstract

We report a 37-year-old man with a history of cirrhosis and methicillin-sensitive staphylococcus aureus (MSSA) bacteremia who presented from a nursing home with 1 week of progressive confusion followed by acute onset of aphasia, forced left eye deviation and right sided weakness. While clinical presentation was concerning for a left middle cerebral artery stroke, MRI was consistent with leukoencephalopathy. The man had been on metronidazole for 2 months for treatment of Clostridium difficile infection. This case exemplifies a stroke mimic to be considered when a patient presents with an acute focal neurological deficit.

References

May 31, 2008·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·Kalpeshkumar PatelAllan R Tunkel

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Citations

Aug 7, 2018·Neurologia Medico-chirurgica·Kensuke TakadaSen Yamagata
Dec 12, 2018·Journal of Neurology·Caspar Godthaab SørensenMette Lindelof

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