Metronomic therapy with cyclophosphamide induces rat lymphoma and sarcoma regression, and is devoid of toxicity

Annals of Oncology : Official Journal of the European Society for Medical Oncology
V R RozadosO Graciela Scharovsky

Abstract

Our aim was to investigate the clinical efficacy and toxicity of metronomic administration of low-dose cyclophosphamide (Cy) in lymphoma and sarcoma rat tumour models. Adult inbred rats were challenged with lymphoma TACB and sarcoma E100 s.c. on day 0. Animals were divided into two groups: group I, control, injected with saline three times a week; and group II, treated with Cy 10 mg/kg three times a week, from day 10 until the tumour was non-palpable, or 5 mg/kg three times a week from day 7. Tumours were measured and animals were weighed twice weekly. Periodic blood samples were taken for determination of urea, creatinine, serum glutamic-oxaloacetic transaminase, lactate dehydrogenase and haematological parameters. The administration of low-dose Cy eradicated established rat lymphomas and sarcomas; there was neither metastatic growth nor recurrence at primary sites for 100% of the lymphomas and 83% of the sarcomas. In addition, the treatment did not cause weight loss, and was devoid of haematological, cardiac, hepatic and renal toxicity. Metronomic administration of Cy at low doses on a thrice weekly schedule to already grown rat lymphomas and sarcomas demonstrated itself to be a successful antitumour therapy that did not caus...Continue Reading

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Citations

Feb 26, 2010·Cancer Chemotherapy and Pharmacology·Antoine ItalianoBinh Bui
Mar 23, 2011·Cellular & Molecular Immunology·Jing LiuBo Huang
May 15, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·L E MainettiO G Scharovsky
May 21, 2013·Journal of the American Veterinary Medical Association·Diane R SchremppDeborah W Knapp
Apr 17, 2009·Current Oncology·O G ScharovskyV R Rozados
Mar 30, 2010·Journal of Cancer Research and Clinical Oncology·Leandro E MainettiO Graciela Scharovsky
Jan 6, 2006·Drug Metabolism Reviews·Jing ZhangYi-Zhun Zhu
Sep 2, 2008·Seminars in Hematology·John P LeonardRebecca Elstrom
Oct 8, 2009·Dose-response : a Publication of International Hormesis Society·Jahangir Satti
Aug 1, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Alberto BottiniAlfredo Berruti
Oct 24, 2019·Birth Defects Research·Vadakkepurath Raj AthiraHanumant Narasinhacharya Yajurvedi
Apr 13, 2017·BMC Complementary and Alternative Medicine·Sarfraz Ahmed, Nor Hayati Othman
Apr 25, 2019·Journal of Oncology·Cem SimsekSuayib Yalcin
Mar 19, 2020·Oxidative Medicine and Cellular Longevity·A F GalS Andrei
May 10, 2017·Evidence-based Complementary and Alternative Medicine : ECAM·Sarfraz AhmedNor Hayati Othman

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