Metyrapone delays surfactant and antioxidant enzyme maturation in developing rat lung

Pediatric Research
I R SosenkoL Frank

Abstract

The surfactant system and the antioxidant enzyme system of the fetal lung have chronologically similar developmental patterns and both can be accelerated by the administration of exogenous glucocorticoids. To test whether the antioxidant enzyme system, like the surfactant system, is regulated, at least in part, by endogenous glucocorticoids, we injected pregnant rats for 3 days prior to delivery with metyrapone, an adrenal 11-beta hydroxylase inhibitor which crosses the placenta and blocks endogenous glucocorticoid synthesis, or saline. Metyrapone offspring had significantly decreased lung tissue disaturated phosphatidylcholine/total phospholipids (p less than 0.05) compared to controls at days 21 and 22 of gestation. Activities of the antioxidant enzymes superoxide dismutase, catalase, and glutathione peroxidase were similarly significantly reduced (p less than 0.01) in the lungs of metyrapone offspring at both gestational days studied. One day premature metyrapone pups demonstrated poorer survival than control pups from 25 min after delivery (44% survival versus 83%, p less than 0.05) to 90 min (6% survival versus 78%, p less than 0.01). These findings of delayed maturation of the surfactant and antioxidant enzyme systems fol...Continue Reading

Citations

Jan 1, 1996·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·A GuptaS N Sanyal
Jan 1, 1991·Free Radical Biology & Medicine·L Frank
Jan 1, 1987·The Journal of Pediatrics·L Frank, I R Sosenko
Jun 1, 2001·Pediatric Research·J S TordayV Rehan
Mar 4, 2003·Pediatric Research·Ilene R S Sosenko, Alan H Jobe
Jan 1, 1991·Experimental Lung Research·F J WaltherH J Forman
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Nov 21, 2017·General and Comparative Endocrinology·Phoebe D Edwards, Rudy Boonstra

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