MF59 adjuvant enhances the antibody response to recombinant hepatitis B surface antigen vaccine in primates

The Journal of Infectious Diseases
P TraquinaG Van Nest

Abstract

The effect of the proprietary adjuvant MF59 on the immunogenicity of a recombinant hepatitis B virus (HBV) vaccine, PreS2+SAg, was investigated in baboons. The magnitude and duration of the antibody response to hepatitis B surface antigen (anti-HBs) induced by the HBV/MF59 vaccine was compared with the same antigen combined with alum and with two licensed alum vaccines. After one immunization, the HBV/MF59 vaccine generated anti-HBs titers >10 mIU/mL in a greater proportion of animals, and mean titers were 26- to 84-fold higher than titers from alum vaccines. After a third immunization, the HBV/MF59 vaccine generated titers 38- to 127-fold higher than alum vaccines. Seven months after the third immunization, HBV/MF59 elicited titers 75- to 472-fold higher than alum vaccines. The dramatic immune response elicited by HBV/MF59 in baboons suggests that MF59 may be a desirable adjuvant for use in improved HBV vaccines for humans.

Citations

Sep 22, 2001·Biomolecular Engineering·D T O'HaganM Singh
Jul 31, 1998·Immunology and Cell Biology·J Kovarik, C A Siegrist
Oct 14, 2004·Immunology and Cell Biology·Nikolai Petrovsky, Julio César Aguilar
Nov 20, 2004·Immunology and Cell Biology·Michael VajdyManmohan Singh
Mar 21, 1998·The Journal of Pharmacy and Pharmacology·D T O'Hagan
May 14, 2010·International Journal of Nanomedicine·Ana Maria Carmona-Ribeiro
Feb 9, 2010·Immunological Investigations·C S NworuV V Temchura
Nov 26, 2010·Expert Review of Vaccines·Antu K Dey, Indresh K Srivastava
Aug 23, 2011·Expert Review of Vaccines·Josianne Nitcheu Tefit, Vincent Serra
Apr 22, 2011·Expert Review of Vaccines·Derek T O'HaganGiuseppe Del Giudice
Dec 22, 2012·Expert Review of Vaccines·Derek T O'HaganGiuseppe Del Giudice
Sep 5, 2008·Expert Review of Vaccines·Sue D XiangMagdalena Plebanski
Oct 27, 2007·Expert Opinion on Biological Therapy·Mazin Barry, Curtis Cooper
Aug 30, 2008·Expert Opinion on Drug Delivery·Yin Hwa Lai, Chong Wang
Sep 25, 2007·International Journal of Medical Microbiology : IJMM·Antje HeitFrank Schmitz
Aug 11, 2007·Vaccine·Anne-Cécile RimaniolPascal Clayette
Mar 6, 2007·Vaccine·J C Aguilar, E G Rodríguez
Nov 15, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elodie BeaumontPhilippe Roingeard
Dec 15, 2004·Journal of Reproductive Immunology·Luis D GiavedoniPeter W Nathanielsz
Oct 4, 2005·Vaccine·Krishna K MurthyJean L Patterson
Dec 23, 2014·International Journal of Cancer. Journal International Du Cancer·Regina HeidenreichMariola Fotin-Mleczek
Jun 5, 2013·International Journal of Biological Macromolecules·Yun YuHuarong Pan
Aug 6, 2003·Expert Review of Vaccines·Derek T O'Hagan, Manmohan Singh
Mar 25, 2015·International Immunopharmacology·Vera GeshevaAndrey Tchorbanov
Apr 29, 2016·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·Esther KisslingUNKNOWN I-MOVE case–control study team
Mar 14, 2017·Expert Review of Vaccines·Nidhi ChauhanUtkarsh Jain
Oct 20, 1998·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·C L VitralA M Gaspar
Nov 5, 1999·Nature Biotechnology·M Singh, D O'Hagan
May 8, 2001·European Journal of Gastroenterology & Hepatology·L Castells, R Esteban
Oct 20, 2005·The Cochrane Database of Systematic Reviews·W Chen, C Gluud
Jul 1, 2006·Current Opinion in HIV and AIDS·Jonathan L Heeney

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