MFehi adipose tissue macrophages compensate for tissue iron perturbations in mice

American Journal of Physiology. Cell Physiology
Merla J HublerAlyssa H Hasty

Abstract

Resident adipose tissue macrophages (ATMs) play multiple roles to maintain tissue homeostasis, such as removing excess free fatty acids and regulation of the extracellular matrix. The phagocytic nature and oxidative resiliency of macrophages not only allows them to function as innate immune cells but also to respond to specific tissue needs, such as iron homeostasis. MFehi ATMs are a subtype of resident ATMs that we recently identified to have twice the intracellular iron content as other ATMs and elevated expression of iron-handling genes. Although studies have demonstrated that iron homeostasis is important for adipocyte health, little is known about how MFehi ATMs may respond to and influence adipose tissue iron availability. Two methodologies were used to address this question: dietary iron supplementation and intraperitoneal iron injection. Upon exposure to high dietary iron, MFehi ATMs accumulated excess iron, whereas the iron content of MFelo ATMs and adipocytes remained unchanged. In this model of chronic iron excess, MFehi ATMs exhibited increased expression of genes involved in iron storage. In the injection model, MFehi ATMs incorporated high levels of iron, and adipocytes were spared iron overload. This acute model ...Continue Reading

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Citations

Jun 13, 2018·Journal of Lipid Research·W Reid Bolus, Alyssa H Hasty
Jan 31, 2020·JCI Insight·Nathan C WinnAlyssa H Hasty
Apr 3, 2020·Immunological Reviews·Heather L CaslinAlyssa H Hasty
Nov 3, 2020·Immunometabolism·Magdalene K Ameka, Alyssa H Hasty
Feb 26, 2021·The Journal of Biological Chemistry·Jin-Seon YookSoonkyu Chung
Aug 3, 2021·American Journal of Physiology. Endocrinology and Metabolism·Nathan C WinnAlyssa H Hasty

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Methods Mentioned

BETA
fluorescence-activated cell sorting
fluorescence-activated cell sorter
atomic absorption spectrometry
FACS
flow cytometry

Software Mentioned

MorphoLibJ
GraphPad Prism

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