Abstract
Stress cardiomyopathy (SCM) is a transient reversible left ventricular dysfunction that more often occurs in women. Symptoms of SCM patients are similar to those of acute coronary syndrome (ACS), but little is known about biomarkers. The goals of this study were to identify the potentially crucial genes and pathways associated with SCM. We analyzed microarray datasets GSE95368 derived from the Gene Expression Omnibus (GEO) database. Firstly, identify the differentially expressed genes (DEGs) between SCM patients in normal patients. Then, the DEGs were used for Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis. Finally, the protein-protein interaction (PPI) network was constructed and Cytoscape was used to find the key genes. In total, 25 DEGs were identified, including 10 upregulated genes and 15 downregulated genes. These DEGs were mainly enriched in ECM-receptor interaction, dilated cardiomyopathy (DCM), human papillomavirus infection, and focal adhesion, whereas in GO function classification, they were mainly enriched in the extracellular region, positive regulation of the multicellular organismal process, establishment of localization, and intracellular vesicle. Seven hub gene...Continue Reading
References
Apr 10, 2004·Stroke; a Journal of Cerebral Circulation·Tomasz DziedzicAndrzej Szczudlik
Sep 15, 2005·The Journal of Clinical Endocrinology and Metabolism·Brett McKinnonRobin Mortimer
Jun 15, 2010·JACC. Cardiovascular Imaging·R Todd HurstA Jamil Tajik
Dec 20, 2012·Coronary Artery Disease·Vecih OduncuCevat Kirma
Mar 5, 2013·The Journal of Clinical Investigation·Nicolas DeroideZiad Mallat
May 24, 2014·Genetics and Molecular Research : GMR·B Y WangS J Tan
Aug 8, 2014·Circulation Journal : Official Journal of the Japanese Circulation Society·Scott W Sharkey, Barry J Maron
Dec 3, 2014·International Journal of Cardiology·Giuseppina NovoSalvatore Novo
Feb 13, 2015·European Heart Journal. Acute Cardiovascular Care·John E Madias
Nov 10, 2015·European Journal of Heart Failure·Alexander R LyonElmir Omerovic
Jan 23, 2016·Echocardiography·Alexandros BriasoulisLuis Afonso
May 27, 2016·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·X ChenW H Jiang
Jan 25, 2017·BMB Reports·Yu Jin JangJong-Hoon Kim
Aug 22, 2017·Frontiers in Cardiovascular Medicine·Timothy P FitzgibbonsGerard P Aurigemma
Aug 23, 2017·Hypertension·Ke-Qiong DengHongliang Li
Nov 21, 2017·Molecular Medicine Reports·Huiying ZhaoXiujiao Qin
Feb 17, 2018·Diabetes Care·Thomas StiermaierIngo Eitel
Jun 5, 2018·Thrombosis and Haemostasis·Joana R ViolaOliver Soehnlein
Oct 13, 2018·Journal of the American College of Cardiology·Horacio Medina de ChazalAntonio Abbate
May 18, 2019·PloS One·Claire JumeauSonia-Athina Karabina
Jul 25, 2019·PloS One·Vindhya MohindraJ K Jena
Aug 29, 2019·ACS Omega·Lu JinThomas Simmet
Sep 27, 2019·The Veterinary Record·Nakita CâmaraPedro Herráez
Nov 16, 2019·BMC Anesthesiology·Yuenong ZhangJingdan Deng
Nov 26, 2019·Medical Ultrasonography·Hongju ZhangNing Ma
Jan 24, 2020·BMJ Case Reports·Myles William Roach, Peter Currie
Jan 26, 2020·Journal of the American Society of Nephrology : JASN·Peter F ZipfelChristine Skerka
Jan 29, 2020·PloS One·Takeshi OnoueHiroshi Arima
Jan 31, 2020·Journal of Cardiovascular Imaging·Mirae Lee
Feb 12, 2020·Annals of Translational Medicine·Li LuXiaomei Guo
Feb 23, 2020·Zhonghua fu chan ke za zhi·J M ShiG J Wang
Jun 1, 2018·Clinical Chemistry·Jeffrey W Meeusen
Feb 29, 2020·BMC Pregnancy and Childbirth·Shengzhu HuangZengnan Mo