PMID: 6166001Jan 1, 1981Paper

Mg and Mc: mutations within the amino-terminal region of glycophorin A

Proceedings of the National Academy of Sciences of the United States of America
H FurthmayrM Metaxas-Bühler

Abstract

M and N are the two common ("normal") alleles at the MN locus of the MNSs blood group system. The antigens M and N that they determine are located within the amino-terminal region of glycophorin A. In the serologically active and glycosylated (*) fragment of glycophorin AN the sequence is Leu-Ser*-Thr*-Thr*-Glu-, and in that of glycophorin AM it is Ser-Ser*-Thr*-Thr*-Gly-. Mg and Mc are very rare ("variant") alleles of M and N; as to the corresponding antigens, Mg is serologically quite distinct from M and N, while Mc is a compound of both. Erythrocytes of genotypes MgN, MgM, MgMg, and McM, which were the object of the present study, contain normal amounts of glycophorin A in their membrane. In glycophorin AMg the amino-terminal sequence is related to that of glycophorin AN by substitution of asparagine for threonine in position 4, and it is nonglycosylated: Leu-Ser-Thr-Asn-Glu-. The corresponding structure of glycophorin AMc is Ser-Ser*-Thr*-Thr*-Glu-; it is thus closely related to that of glycophorin AN and AM, by substitution of the amino acids in positions 1 or 5, respectively. All of these substitutions can be explained by single base changes. The distinctions in chemical structure not only confirm the location of M and N ...Continue Reading

References

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Citations

Apr 1, 1983·Biochemical Genetics·O O BlumenfeldW W Socha
Jul 28, 1983·Biochimica Et Biophysica Acta·R L Batstone-CunninghamK Dill
Aug 26, 2003·Legal Medicine·Hajime MizukamiKento Ogawa
Dec 9, 2000·Vox Sanguinis·A AkaneH Shiono
Sep 1, 1991·Transfusion Medicine·C M Giles
Jan 1, 1989·The International Journal of Biochemistry·A L Barsoum, V P Bhavanandan
Jul 1, 1992·Transfusion Medicine Reviews·P TippettD J Anstee
Jul 1, 1990·Transfusion Medicine Reviews·D Blanchard
Dec 1, 1991·Baillière's Clinical Haematology·C H HuangO O Blumenfeld
Jan 1, 1985·Vox Sanguinis·M E NicholsP Rubinstein
Jan 1, 1983·Vox Sanguinis·J E Lawe, L L LaRoche
Nov 1, 1983·International Journal of Peptide and Protein Research·B Ferrari, A A Pavia
Nov 1, 1984·International Journal of Peptide and Protein Research·B Ferrari, A A Pavia
Aug 1, 1989·Biological Chemistry Hoppe-Seyler·W DahrK Beyreuther
Apr 1, 1984·Hoppe-Seyler's Zeitschrift für physiologische Chemie·D BlanchardJ P Cartron

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