MG160, a membrane protein of the Golgi apparatus which is homologous to a fibroblast growth factor receptor and to a ligand for E-selectin, is found only in the Golgi apparatus and appears early in chicken embryo development

Experimental Cell Research
A StieberN K Gonatas

Abstract

While over 20 intrinsic proteins of the Golgi apparatus have been identified and sequenced, there is no information on their developmental history, i.e., whether all Golgi proteins are expressed simultaneously or whether there is a hierarchical or stage-specific order of their expression during embryonic development. In this study we have examined the emergence and distribution of MG160 during the development of chicken embryos. MG160 is a conserved membrane sialoglycoprotein of the Golgi apparatus of most cells displaying over 90% amino acid sequence identities with two apparently unrelated molecules, namely CFR, a chicken fibroblast growth factor receptor, and ESL-1, a ligand for E-selectin (Gonatas et al., J. Biol. Chem. 1989, 264, 646-653; Burrus and Olwin, J. Biol. Chem. 1989, 264, 18647-18653; Burrus et al., Mol. Cell Biol. 1992, 12, 5600-5609; Gonatas et al., J. Cell Sci. 108, 457-467; Steegmaier et al., Nature 1995, 373, 615-620). This study was carried out by in situ hybridization, using a 56-mer antisense probe for the chicken homologue of MG160 which differs only by four bases from the corresponding segment of the rat cDNA and by immunocytochemistry and Western blotting using a polyclonal antiserum against MG160. The...Continue Reading

Citations

Apr 17, 2013·Proceedings of the National Academy of Sciences of the United States of America·Tao YangBrendan Lee
May 28, 1996·Proceedings of the National Academy of Sciences of the United States of America·Z MourelatosM C Dal Canto
Mar 18, 2000·The Journal of Biological Chemistry·A KorimilliS H Guttentag
Jun 19, 2001·The Journal of Biological Chemistry·M K WildD Vestweber
Aug 15, 2001·Laboratory Investigation; a Journal of Technical Methods and Pathology·F HenselH P Vollmers
May 6, 2003·Journal of Human Genetics·Kensuke OchiYusuke Nakamura
Dec 5, 1998·Comptes rendus de l'Académie des sciences. Série III, Sciences de la vie·A H Monsoro-BurqN K Gonatas
Aug 8, 1998·Trends in Cell Biology·S Munro

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