Mg2+ modulates membrane lipids in vascular smooth muscle: a link to atherogenesis

FEBS Letters
G A MorrillB M Altura

Abstract

Epidemiological studies associate low dietary magnesium intake with an increased incidence of ischemic heart disease and sudden cardiac death. We have used proton-magnetic resonance (1H-NMR) techniques and Mg2+-selective electrodes to monitor changes in lipid extracts of aortic and cerebrovascular smooth muscle as extracellular ionized magnesium ion concentration ([Mg2+]o) is lowered. We have found that, within the pathophysiological range of Mg2+ concentrations, fatty acid chain length and double bond content are progressively reduced as [Mg2+]o is lowered. In contrast, the plasmalogen content is progressively increased. A concomitant decrease in fatty acid chain length and double bonds indicates oxidation of double bonds resulting in truncation of the fatty acids. A decrease in lipid oxidation in the presence of elevated Mg2+ could contribute to the apparent protective role of increased Mg2+ intake on vascular function in humans.

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Citations

May 13, 2009·Molecular Pharmaceutics·Chiranjeevi PeetlaVinod Labhasetwar
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Feb 1, 2005·Life Sciences·Nepton SoltaniSaleh Zahedi Asl
Aug 14, 2010·American Journal of Hypertension·Takanao HashimotoYutaka Imai
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