MG53-mediated cell membrane repair protects against acute kidney injury

Science Translational Medicine
Pu DuannJianjie Ma

Abstract

Injury to the renal proximal tubular epithelium (PTE) represents the underlying consequence of acute kidney injury (AKI) after exposure to various stressors, including nephrotoxins and ischemia/reperfusion (I/R). Although the kidney has the ability to repair itself after mild injury, insufficient repair of PTE cells may trigger inflammatory and fibrotic responses, leading to chronic renal failure. We report that MG53, a member of the TRIM family of proteins, participates in repair of injured PTE cells and protects against the development of AKI. We show that MG53 translocates to acute injury sites on PTE cells and forms a repair patch. Ablation of MG53 leads to defective membrane repair. MG53-deficient mice develop pronounced tubulointerstitial injury and increased susceptibility to I/R-induced AKI compared to wild-type mice. Recombinant human MG53 (rhMG53) protein can target injury sites on PTE cells to facilitate repair after I/R injury or nephrotoxin exposure. Moreover, in animal studies, intravenous delivery of rhMG53 ameliorates cisplatin-induced AKI without affecting the tumor suppressor efficacy of cisplatin. These findings identify MG53 as a vital component of reno-protection, and targeting MG53-mediated repair of PTE c...Continue Reading

References

Mar 1, 1987·Zhongguo yao li xue bao = Acta pharmacologica Sinica·L W WangW C Li
Nov 1, 1986·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·R SafirsteinJ Guttenplan
Jun 17, 1994·Annals of the New York Academy of Sciences·J H KramerW B Weglicki
Aug 26, 1997·Biochemistry·G SpeelmansB de Kruijff
Sep 13, 2001·American Journal of Physiology. Renal Physiology·W LieberthalJ S Levine
May 9, 2003·Nature·Dimple BansalKevin P Campbell
Oct 23, 2003·Annual Review of Cell and Developmental Biology·Paul L McNeil, Richard A Steinhardt
Jun 2, 2005·Nature Reviews. Molecular Cell Biology·Paul L McNeil, Tom Kirchhausen
Jul 4, 2007·The Journal of Clinical Investigation·Renzhi HanKevin P Campbell
Apr 17, 2008·The Journal of Clinical Investigation·Takaharu IchimuraJoseph V Bonventre
Nov 26, 2008·The Journal of Biological Chemistry·Chuanxi CaiJianjie Ma
Dec 2, 2008·Nature Cell Biology·Chuanxi CaiJianjie Ma
Jan 6, 2009·Nature Cell Biology·Paul McNeil
Sep 22, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Magnus JensenWilly Nerdal
Dec 17, 2009·Journal of Biomedicine & Biotechnology·Akihiko SaitoTetsuro Takeda
Dec 19, 2009·Journal of the American Society of Nephrology : JASN·Bernd SchröppelJohn P Vella
Jun 3, 2010·Circulation·Chun-Mei CaoRui-Ping Xiao
Mar 18, 2011·Journal of Neuropathology and Experimental Neurology·Leigh B WaddellSandra T Cooper
Mar 25, 2011·Transgenic Research·Michiko SekineHiromichi Yonekawa
May 14, 2011·Journal of the American Society of Nephrology : JASN·Hans-Joachim Anders, Daniel A Muruve
Oct 5, 2011·The AAPS Journal·Tobias Christian Fuchs, Philip Hewitt
Nov 3, 2011·The Journal of Clinical Investigation·Joseph V Bonventre, Li Yang
Nov 8, 2011·Methods in Molecular Biology·Heather M Wilson, Keith N Stewart
Nov 9, 2011·Nature Medicine·Holger K Eltzschig, Tobias Eckle
Nov 10, 2011·Toxins·Ronald P MillerWilliam Brian Reeves
Jan 19, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Peihui LinJianjie Ma
Feb 22, 2012·The Journal of Thoracic and Cardiovascular Surgery·Andrew Shaw
May 15, 2012·Pharmacological Reports : PR·Amrit Pal SinghRavi Dhawan
Jun 23, 2012·Science Translational Medicine·Noah WeislederJianjie Ma
Aug 10, 2012·Physiology·Erik I ChristensenRikke Nielsen
Nov 13, 2012·The Journal of Clinical Investigation·Ming-Zhi ZhangRaymond C Harris
Dec 4, 2012·Cancer Research·Reena ShakyaThomas Ludwig
Dec 19, 2012·Nature Reviews. Nephrology·Kelvin C W LeungMatthew T James
Dec 18, 2013·The Journal of Biological Chemistry·Nga NguyenYoung-Gyu Ko

❮ Previous
Next ❯

Citations

Oct 4, 2015·Seminars in Cell & Developmental Biology·N W AndrewsT Castro-Gomes
Jun 15, 2016·The Journal of Cell Biology·Alexis R DemonbreunElizabeth M McNally
Jan 4, 2018·Nutrients·Pei-Hui LinJianjie Ma
Feb 12, 2019·Journal of the American Heart Association·T M Ayodele AdesanyaJianjie Ma
Apr 23, 2017·Molecular Pharmacology·Yan ZhangRui-Ping Xiao
Sep 7, 2017·Science Signaling·Adam HornJyoti K Jaiswal
Apr 29, 2020·Cells·Md Shahabe Uddin TalukderShigehiko Yumura
Nov 4, 2015·Physiology·Alisa D BlazekNoah Weisleder
May 14, 2016·BMB Reports·Tao TanJianjie Ma
Jun 30, 2018·American Journal of Respiratory Cell and Molecular Biology·Nagaraja NagreXiaoli Zhao
Nov 16, 2018·JCI Insight·Hiroko Ishiwata-EndoJoel Moss
Mar 7, 2020·Diabetes·Qiang WangJianjie Ma
Aug 26, 2015·The Journal of Biological Chemistry·Haichang LiJianjie Ma
Jun 10, 2018·Experimental & Molecular Medicine·Jun Sub ParkYoung-Gyu Ko
Jun 23, 2019·International Journal of Molecular Sciences·Sara J HolditchCharles L Edelstein
Oct 3, 2020·Cardiovascular Toxicology·Wenhua JiangHeng Ma
Mar 2, 2019·Journal of Cellular Physiology·Xu ChenQijun Zheng
Sep 24, 2019·The Journal of Clinical Investigation·Alexis R DemonbreunElizabeth M McNally
Apr 10, 2020·PloS One·Brian J PaleoNoah Weisleder
Jan 20, 2021·Cell Discovery·Catarina Dias, Jesper Nylandsted
Jan 28, 2021·Military Medicine·Bryan A WhitsonGreg J Beilman
Feb 11, 2021·PloS One·Clothilde PhilouzePhilippe Delerive
Nov 27, 2020·Frontiers in Physiology·Dathe Z Benissan-MessanPeter H U Lee
May 17, 2017·Current Opinion in Cell Biology·Ana Joaquina Jimenez, Franck Perez
Apr 15, 2021·BMC Biology·Dustin A AmmendoliaJohn H Brumell
Apr 24, 2021·Bone·Mackenzie L HaganMeghan E McGee-Lawrence
May 31, 2021·Current Opinion in Pharmacology·Bryan A WhitsonJianjie Ma
Jun 30, 2021·Cell & Bioscience·Weina ZhongPeter H U Lee
Jul 10, 2021·Journal of Cellular and Molecular Medicine·Jinling DongLiqun Wang

❮ Previous
Next ❯

Related Concepts

Related Feeds