MG98, a second-generation DNMT1 inhibitor, in the treatment of advanced renal cell carcinoma

Cancer Investigation
Robert J AmatoRobert E Martell

Abstract

In carcinogenesis, methylation of DNA promoter regions results in inactivation of tumor-suppressing genes. MG98 was designed to inhibit DNA methyltransferases enzyme 1 production. This multicenter study explored two schedules of MG98 with Interferon-α-2β to identify schedule and dose for patients with metastatic RCC. Doses of IFN 9 MIU/MG98 125 mg/m(2) for a continuous schedule and IFN 9 MIU/MG98 200 mg/m(2) for an intermittent schedule were considered the MTDs. Treatment resulted in one PR and eight SD. MG98 combined with IFN was safe and resulted in clinical activity.

References

May 12, 1995·The Journal of Biological Chemistry·A R MacLeodM Szyf
Oct 11, 1994·Proceedings of the National Academy of Sciences of the United States of America·J G HermanW M Linehan
Jul 1, 1994·Trends in Pharmacological Sciences·M Szyf
Jan 1, 1996·Pharmacology & Therapeutics·M Szyf
Apr 16, 1998·Pharmacology & Therapeutics·S Agrawal, R P Iyer
Apr 5, 2002·Nature·Ina RheeBert Vogelstein
Dec 24, 2002·Nature Genetics·Marie-France RobertA Robert MacLeod
Jun 20, 2003·European Urology·Ivar BleumerPeter F A Mulders
Aug 2, 2003·The New England Journal of Medicine·James C YangSteven A Rosenberg
Nov 25, 2003·The New England Journal of Medicine·James G Herman, Stephen B Baylin
Jul 13, 2004·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Arifa PasicThomas G Sutedja
Oct 27, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wade G AllemanJames R Vasselli
Feb 3, 2006·International Journal of Cancer. Journal International Du Cancer·Eri AraiSetsuo Hirohashi
Jan 12, 2007·The New England Journal of Medicine·Bernard EscudierUNKNOWN TARGET Study Group
Jan 24, 2007·CA: a Cancer Journal for Clinicians·Ahmedin JemalMichael J Thun
Dec 17, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Thomas E HutsonRobert A Figlin

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Citations

Aug 3, 2014·Archives of Toxicology·Antonella Di CostanzoLucia Altucci
Jan 16, 2014·Journal of Experimental & Clinical Cancer Research : CR·Jun GaoZhaoshen Li
Jul 21, 2015·Chromosoma·Anne C MirabellaTill Bartke
Oct 30, 2012·Molecular Oncology·Angela NebbiosoLucia Altucci
Feb 13, 2017·Cancer Treatment Reviews·J F LinnekampH W M van Laarhoven
Aug 25, 2019·Cells·Marzena CiechomskaWlodzimierz Maslinski
Oct 23, 2019·Nature Reviews. Nephrology·Cissy YongChristian Frezza
Dec 31, 2016·Oncotarget·Inês FaleiroPedro Castelo-Branco
Oct 11, 2013·Future Oncology·Gaetano BertinoMichele Malaguarnera
Jan 10, 2017·Biomolecules·Omar Castillo-AguileraLaurence Goossens
Apr 20, 2019·Der Internist·M WallbachM J Koziolek
May 1, 2018·Frontiers in Pharmacology·Ângela Marques-MagalhãesCarmen Jerónimo
Aug 14, 2020·Cells·Sandra P NunesJesús M Paramio
Feb 6, 2021·The FEBS Journal·Shengrui Feng, Daniel D De Carvalho
Feb 12, 2017·Pharmacology & Therapeutics·Subhankar Biswas, C Mallikarjuna Rao

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