mGlu1α-dependent recruitment of excitatory GABAergic input to neocortical Cajal-Retzius cells.

Neuropharmacology
Kathleen E Cosgrove, Gianmaria Maccaferri

Abstract

Cajal-Retzius cells are thought to play an important role for cortical development, and receive primarily spontaneous GABAergic input mediated by GABA(A) receptors. However, neither the effects of synaptically-released GABA on their excitability nor the cellular source(s) of spontaneous GABAergic currents have been yet determined. By directly recording electrophysiological responses from identified Cajal-Retzius cells of the CXCR4-EGFP mouse, we show that GABAergic input can trigger supra-threshold responses, and that the pharmacological activation of mGlu1α receptors with the group I agonist DHPG powerfully increases the frequency of spontaneous GABAergic currents. These effects appeared mediated by a network mechanism, because responses to DHPG were completely prevented both by surgical disconnection of layer I from lower layers and by exposure of slices to TTX. We propose that the cellular source underlying the observed effect of DHPG are layer I-targeting Martinotti-like interneurons, which we show express functional group I mGluRs and respond to DHPG with supra-threshold depolarization already at early developmental stages. In conclusion, our work suggests that conditions of enhanced glutamate release may be critical at ea...Continue Reading

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Citations

Mar 29, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Giulia Quattrocolo, Gianmaria Maccaferri
Jan 18, 2014·Current Opinion in Neurobiology·Heiko J LuhmannWerner Kilb
Jul 6, 2014·Frontiers in Neuroanatomy·Verónica Martínez-Cerdeño, Stephen C Noctor
Jul 30, 2019·Frontiers in Cellular Neuroscience·Tim KroonRhiannon M Meredith
May 29, 2021·Development·Frédéric CauseretOriane Blanquie

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