mGlu3 receptor and astrocytes: partners in neuroprotection

Neuropharmacology
Daniela DurandMercedes Lasaga

Abstract

Astrocytes are currently studied intensively because of their now highlighted relevance as key players with neurons that modulate a wide range of central functions, from synaptic plasticity and synaptogenesis to regulation of metabolic and neuroinflammatory processes. Since the discovery of mGlu3 receptors on astrocytes, accumulating evidence supports a role of these receptors not only in maintaining synaptic homeostasis and treating psychiatric disorders but also in promoting astrocyte survival in several pathologic conditions. This review focuses on providing up-to-date knowledge regarding effects of activating astroglial mGlu3 receptors on psychiatric disorders, astrocyte and neuronal survival, and neurodegenerative diseases. This article is part of a Special Issue entitled 'Metabotropic Glutamate Receptors'.

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Citations

Aug 19, 2014·Journal of Neuroscience Research·Sofya AbazyanMikhail Pletnikov
Mar 1, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Meng-Lin LiWen-Jun Gao
Apr 28, 2017·Molecular Brain·James MaksymetzP Jeffrey Conn
Nov 14, 2019·Frontiers in Pharmacology·Ilaria Dal PràAnna Chiarini
Jun 28, 2018·Acta Pharmacologica Sinica·Yong-Jian HuJian-Feng Liu
Nov 30, 2018·Frontiers in Molecular Neuroscience·Simona Federica SpampinatoFilippo Caraci
Aug 29, 2020·Neurochemistry International·Juan TuratiMercedes Lasaga
Aug 26, 2021·Neuropharmacology·Ulyana LaloYuriy Pankratov

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