PMID: 25773792Mar 17, 2015Paper

MGMT-B gene promoter hypermethylation in patients with inflammatory bowel disease - a novel finding

Asian Pacific Journal of Cancer Prevention : APJCP
Pooneh MokarramMahvash Alizade Naini

Abstract

Inflammatory bowel disease (IBD) is a disease strongly associated with colorectal cancer (CRC) as a well-known precancerous condition. Alterations in DNA methylation and mutation in K-ras are believed to play an early etiopathogenic role in CRC and may also an initiating event through deregulation of molecular signaling. Epigenetic silencing of APC and SFRP2 in the WNT signaling pathway may also be involved in IBD-CRC. The role of aberrant DNA methylation in precancerous state of colorectal cancer (CRC) is under intensive investigation worldwide. The aim of this study was to investigate the status of promoter methylation of MGMT-B, APC1A and SFRP2 genes, in inflamed and normal colon tissues of patients with IBD compared with control normal tissues. A total of 52 IBD tissues as well as corresponding normal tissues and 30 samples from healthy participants were obtained. We determined promoter methylation status of MGMT-B, SFRP2 and APC1A genes by chemical treatment with sodium bisulfite and subsequent MSP. The most frequently methylated locus was MGMT-B (71%; 34 of 48), followed by SFRP2 (66.6 %; 32 of 48), and APC1A (43.7%; 21 of 48). Our study demonstrated for the first time that hypermethylation of the MGMT-B and the SFRP2 gen...Continue Reading

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Citations

Oct 30, 2016·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·Mozhdeh ZamaniPooneh Mokarram
Oct 3, 2020·World Journal of Gastrointestinal Oncology·Amirsaeed Sabeti AghabozorgiEbrahim Eftekhar
Jan 9, 2020·World Journal of Clinical Cases·Mostafa Moradi SarabiEbrahim Eftekhar
May 26, 2016·Asian Pacific Journal of Cancer Prevention : APJCP·M Alizade NainiM Borji
May 1, 2021·International Journal of Molecular Sciences·Sarah Teuber-HanselmannAndreas Junker

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