MGN-3/Biobran, modified arabinoxylan from rice bran, sensitizes human breast cancer cells to chemotherapeutic agent, daunorubicin

Cancer Detection and Prevention
Sastry Gollapudi, Mamdooh Ghoneum

Abstract

MGN-3/Biobran, a modified form of arabinoxylan from rice bran, is a potent biological response modifier (BRM). Our previous studies demonstrated that MGN-3 sensitizes human leukemia cells to death receptor [CD95]-induced apoptosis [Ghoneum M, Gollapudi S. MGN-3 sensitizes human T cell leukemia cells to death receptor (CD95)-induced apoptosis. Cancer Lett 2003;201:41-9]. In this study, we evaluated the chemo-sensitizing activity of MGN-3 against human breast cancer cells (BCCs) in vitro. BCCs (MCF-7 and HCC70 cells) were cultured with different concentrations of daunorubicin (DNR) (from 1x10(-9) to 1x10(-6)M) in the presence or absence of selected concentrations of MGN-3 (100-1000mug/ml) for 3 days. Cancer cell survival was determined by MTT assay and drug accumulation was determined by flow cytometry. Treatment with MGN-3 increased susceptibility of BCCs to DNR (5.5-fold for MCF-7 and 2.5-fold for HCC70 cells) as compared to BCCs treated with DNR alone. The sensitizing effect of MGN-3 was associated with increased accumulation of DNR in cancer cells. Our data demonstrate that MGN-3 is an effective chemo-sensitizer and may represent a potential novel adjuvant for the treatment of breast cancer.

References

Sep 1, 1992·Cancer Metastasis Reviews·J A Hickman
May 1, 1980·Irish Journal of Medical Science·K H MillsG M Mullins
Nov 1, 1994·Current Opinion in Oncology·S J Martin, D R Green
Aug 17, 1996·Mutation Research·B J SandersonW A Denny
Feb 27, 1999·The New England Journal of Medicine·S E LipshultzS D Colan
Dec 1, 2001·Journal of Biochemistry·N MiyoshiM Isemura
Jun 6, 2003·Pharmacology & Toxicology·Yuzo Endo, Hiroshi Kanbayashi
Jul 18, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Hui-Fen LiaoYu-Jen Chen

❮ Previous
Next ❯

Citations

Mar 26, 2004·Cancer Detection and Prevention·Mamdooh Ghoneum, Sastry Gollapudi
Jan 23, 2016·Carbohydrate Polymers·Mihiri MendisSenay Simsek
Jun 25, 2009·International Journal of Biological Macromolecules·Li WangZhengxing Chen
Nov 23, 2017·Integrative Cancer Therapies·Nariman K Badr El-DinMamdooh Ghoneum
Mar 27, 2009·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Anil Minocha
Jan 8, 2021·Foods·Marco SpaggiariMaría Dolores Del Castillo Bilbao
May 1, 2021·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Soo Liang OoiSung-Joo Hwang
Jul 24, 2021·Carbohydrate Polymers·Mingjun ZhangJianbin Li

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis