PMID: 9419236Feb 21, 1998Paper

Mhc allelic diversity and modern human origins

Journal of Molecular Evolution
R E Hickson, R L Cann

Abstract

Thirty complete coding sequences of human major histocompatibility complex (Mhc) class II DRB alleles, spanning 237 codons, were analyzed for phylogenetic information using distance, parsimony, and likelihood approaches. Allelic genealogies derived from different parts of the coding sequence (exon 2, the 5' and 3' ends of exon 2, respectively, and exons 3-6) were compared. Contrary to prior assertions, a rigorous analysis of allelic genealogies in this gene family cannot be used to justify the claim that the lineage leading to modern humans contained on average at least 100,000 individuals. Phylogenetic inferences based upon the exon 2 region of the DRB loci are complicated by selection and recombination, so this part of the gene does not provide a complete and accurate view of allelic relationships. Attempts to reconstruct human history from genetic data must use realistic models which consider the complicating factors of nonequilibrium populations, recombination, and different patterns of selection.

Citations

Jun 19, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·L B JordeA R Rogers
Mar 31, 2005·Trends in Genetics : TIG·Carles VilàHans Ellegren
Jul 2, 2003·Molecular Immunology·Hanady SamahaNoha Hakime
Mar 21, 1998·Nature Genetics·T F BergströmU Gyllensten
Sep 30, 2005·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·Zeyun Yu, Chandrajit Bajaj
Nov 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·K Kotsch, R Blasczyk

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