MHC and Evolution in Teleosts

Biology
Unni Grimholt

Abstract

Major histocompatibility complex (MHC) molecules are key players in initiating immune responses towards invading pathogens. Both MHC class I and class II genes are present in teleosts, and, using phylogenetic clustering, sequences from both classes have been classified into various lineages. The polymorphic and classical MHC class I and class II gene sequences belong to the U and A lineages, respectively. The remaining class I and class II lineages contain nonclassical gene sequences that, despite their non-orthologous nature, may still hold functions similar to their mammalian nonclassical counterparts. However, the fact that several of these nonclassical lineages are only present in some teleost species is puzzling and questions their functional importance. The number of genes within each lineage greatly varies between teleost species. At least some gene expansions seem reasonable, such as the huge MHC class I expansion in Atlantic cod that most likely compensates for the lack of MHC class II and CD4. The evolutionary trigger for similar MHC class I expansions in tilapia, for example, which has a functional MHC class II, is not so apparent. Future studies will provide us with a more detailed understanding in particular of non...Continue Reading

References

Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·H OnoJ Klein
May 20, 1991·Journal of Molecular Biology·M A SaperD C Wiley
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·K HashimotoY Kurosawa
Jan 1, 1993·Immunogenetics·H OnoJ Klein
Jan 1, 1996·Immunogenetics·K M Miller, R E Withler
May 1, 1996·Developmental and Comparative Immunology·T KatagiriM Sakai
Nov 1, 1996·Developmental and Comparative Immunology·J D HansenL Du Pasquier
Jan 1, 1997·Developmental and Comparative Immunology·U B GodwinT J McConnell
Apr 4, 1998·Immunogenetics·R GraserJ Klein
Jun 6, 1998·Proceedings of the National Academy of Sciences of the United States of America·N LeeD E Geraghty
Jan 23, 1999·Immunological Reviews·T J McConnellB J Cuthbertson
Jan 23, 1999·Immunological Reviews·R J StetG F Wiegertjes
Jun 25, 1999·Immunogenetics·B P ShumP Parham
May 9, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·V MichalováJ Klein
Feb 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B P ShumP Parham
Dec 26, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kazuhiko AoyagiTeruyuki Nakanishi
Jan 5, 2002·Immunity·D B Moody, S A Porcelli
Feb 28, 2002·Immunogenetics·Kristina M MillerAngela D Schulze
Aug 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Corine P KruiswijkRené J M Stet
Oct 25, 2002·Proceedings. Biological Sciences·Jakob LohmTorbjörn von Schantz
Mar 20, 2004·Critical Reviews in Immunology·René J M StetBrian Dixon
Mar 7, 2006·Immunogenetics·Johannes Martinus DijkstraMitsuru Ototake
Jun 24, 2006·Immunogenetics·Kristina M MillerAngela D Schulze
Oct 13, 2006·Immunogenetics·Akie SatoJan Klein
Oct 24, 2006·Developmental and Comparative Immunology·Y PaltiJ D Hansen

❮ Previous
Next ❯

Citations

Apr 28, 2019·Cells·Takuya Yamaguchi, Johannes M Dijkstra
Feb 18, 2017·Scientific Reports·Yu-Hang ZhangXiangyin Kong
Oct 9, 2019·Biology Letters·Arseny DubinLars Martin Jakt
Nov 13, 2019·Immunogenetics·Arvind Y M SundaramUnni Grimholt
Jan 15, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Tereza AlmeidaAna Veríssimo
May 13, 2020·Proceedings. Biological Sciences·William J Bradshaw, Dario Riccardo Valenzano
Jun 17, 2020·Journal of Fish Diseases·Helene L E MidttunIda B Johansen
Jan 18, 2020·Genome Biology and Evolution·Yukako Katsura, Masatoshi Nei
Apr 8, 2020·Journal of Veterinary Research·Michał StosikWiesław Deptuła
Jul 25, 2018·Immunogenetics·Keith T BallingallSteven G E Marsh
Nov 27, 2018·Genome Biology and Evolution·Piotr MiniasPeter O Dunn
Jul 3, 2016·Immunogenetics·Eva-Stina EdholmJacques Robert
Jun 13, 2018·Frontiers in Immunology·Leon GrayferMiodrag Belosevic
Jul 12, 2017·Immunogenetics·Anthony B Wilson
Aug 1, 2020·Science·Jeremy B SwannThomas Boehm
Oct 31, 2020·Frontiers in Immunology·Unni GrimholtArvind Y M Sundaram
Dec 7, 2020·Developmental and Comparative Immunology·Yasuko HonjoTatsuo Ichinohe
Oct 29, 2020·Development, Growth & Differentiation·Myung ChungTeruhiro Okuyama
Nov 24, 2020·Immunogenetics·Unni Grimholt, Morten Lukacs
Feb 3, 2021·Molecular Biology and Evolution·Nicole M PatersonMatthew F Barber
Mar 12, 2019·Developmental and Comparative Immunology·Mohammed A El-MagdTarek M Mohamed
Sep 1, 2021·Nature Genetics·Andrew W ThompsonIngo Braasch

❮ Previous
Next ❯

Software Mentioned

Ensembl
OnmyDAA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.