PMID: 2507727Oct 1, 1989Paper

MHC antigen induction by interferon gamma on cultured mouse pancreatic beta cells and macrophages. Genetic analysis of strain differences and discovery of an "occult" class I-like antigen in NOD/Lt mice

The Journal of Experimental Medicine
E H LeiterS M Worthen

Abstract

This study provides a basis for understanding the wide variations reported in the literature in IFN-gamma inducibility of class II MHC antigens on murine beta cells. Inducibility is not an intrinsic property of all mouse beta cells, but instead depends upon strain- (and tissue-) specific response modifying factors. This was demonstrated by comparison of constitutive and IFN-gamma-induced class I and class II MHC gene products on cultured islet cell monolayers. Islet cultures were established from autoimmune diabetes-prone NOD/Lt mice, diabetes-resistant NON/Lt and CBA/J mice, as well as F1 hybrids between these latter two strains and NOD/Lt. Cultures of peritoneal macrophages (M phi) from each strain were established as controls. After 3 wk of culture (with incubation in the presence or absence of IFN-gamma during the last 6 d), constitutive expression as well as IFN-gamma induction of class I MHC antigen expression was demonstrated on NOD/Lt and NON/Lt islet cells by antibody plus complement-mediated cytotoxicity. Although CBA/J islets and M phi did not maintain constitutive class I or class II antigen expression in culture in the absence of IFN-gamma, class I H-2Kk antigen was IFN-gamma inducible. Whereas IFN-gamma-induced cl...Continue Reading

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Citations

Dec 1, 1995·Diabetes/metabolism Reviews·A G Baxter, A Cooke
Jul 20, 2007·Immunology and Cell Biology·Ayelet KaminitzNadir Askenasy
Oct 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·D V SerrezeE H Leiter
May 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Emma E Hamilton-WilliamsRobyn M Slattery
May 12, 2015·European Journal of Immunology·Yuxing ZhaoHelen E Thomas
Mar 19, 2013·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Sanja StevanovićJ H Frederik Falkenburg
Sep 30, 2016·Clinical Reviews in Allergy & Immunology·Ayelet KaminitzNadir Askenasy
Apr 1, 1994·Clinical and Experimental Immunology·M G CavalloR Thorpe
Nov 21, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·A Y SavinovA V Chervonsky
Jul 9, 1999·Diabetes/metabolism Research and Reviews·D W Gray
May 1, 1991·Journal of Virology·M T Barger, J E Craighead

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