PMID: 9008309Dec 1, 1996Paper

MHC class II alleles and haplotypes in patients with pemphigus vulgaris from India

Tissue Antigens
J C DelgadoE J Yunis

Abstract

Pemphigus vulgaris (PV) is a blistering disease of the skin and mucous membranes characterized by an autoantibody response against a keratinocyte adhesion molecule, desmoglein 3, causing acantholysis and blister formation. We compared high resolution MHC class II alleles and haplotype frequencies (HLA-DRB, DQA1 and DQB1) in 37 patients with PV to 89 haplotypes of normal relatives from New Delhi and Ahmedabad. We found that PV patients had significantly increased frequencies of DRB1*1404 (P < 0.0001), DQA1*0101 (P = 0.001), and DQB1*0503 (P < 0.0001). These associations were due to the increased frequencies of the haplotype HLA-DRB1*1404, DRB3*0202, DQA1*0101, DQB1*0503 in patients compared to control haplotypes (p < 0.0001). Also, patients from Ahmedabad had a significant increase in HLA-DQB1*0302 (p = 0.03). An identical amino acid sequence (Leu-Leu-Glu-Arg-Arg-Arg-Ala-Glu), in positions 67-74 of the beta domain of DRB alleles is restricted to some DR14 alleles. Therefore, there are three possible explanations for class II allele involvement in autoantibody in PV patients with class II haplotypes marked by HLA-DR14. First, the class II alleles could be markers for an unidentified susceptibility gene in linkage disequilibrium w...Continue Reading

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Citations

Jan 1, 2004·Human Immunology·Ephraim GazitRon Loewenthal
May 5, 2005·Journal of Autoimmunity·François TronMourad Ben Ayed
Apr 24, 1999·The British Journal of Dermatology·C ScullyJ J Gilkes
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May 9, 2012·The British Journal of Dermatology·L YanK Zeng
Jan 3, 2013·International Journal of Dermatology·Cilem Kaya KocOlcay Yegin
Apr 5, 2013·International Journal of Immunogenetics·Z PárnickáM Buc
Jan 13, 2006·The British Journal of Dermatology·F CaponK E Harman
Jan 16, 2015·Archives of Dermatological Research·Erkan AlpsoySoner Uzun
May 15, 2016·Human Immunology·Adriana Martinelli SalathielAna Maria Roselino
Sep 13, 2002·Journal of the European Academy of Dermatology and Venereology : JEADV·F FemianoC Scully
Oct 24, 2002·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·Crispian Scully, Stephen J Challacombe
Jul 20, 2004·Oncogene·Dweepanita DasMichael J Imperiale
Aug 30, 2018·Frontiers in Medicine·Dan VodoEli Sprecher
Mar 28, 2018·Indian Journal of Dermatology, Venereology and Leprology·Anuradha PriyadarshiniVisalakshi Jayaseelan
Aug 12, 2021·Indian Journal of Dermatology, Venereology and Leprology·Sanjeev HandaDipankar De

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