MHC haplotype and susceptibility to experimental infections (Salmonella Enteritidis, Pasteurella multocida or Ascaridia galli) in a commercial and an indigenous chicken breed

Veterinary Immunology and Immunopathology
T W SchouH R Juul-Madsen

Abstract

In three independent experimental infection studies, the susceptibility and course of infection of three pathogens considered of importance in most poultry production systems, Ascaridia galli, Salmonella Enteritidis and Pasteurella multocida were compared in two chicken breeds, the indigenous Vietnamese Ri and the commercial Luong Phuong. Furthermore, the association of the Major Histocompatibility Complex (MHC) with disease-related parameters was evaluated, using alleles of the LEI0258 microsatellite as markers for MHC haplotypes. The Ri chickens were found to be more resistant to A. galli and S. Enteritidis than commercial Luong Phuong chickens. In contrast, the Ri chickens were more susceptible to P. multocida, although production parameters were more affected in the Luong Phuong chickens. Furthermore, it was shown that the individual variations observed in response to the infections were influenced by the MHC. Using marker alleles of the microsatellite LEI0258, which is located within the MHC region, several MHC haplotypes were identified as being associated with infection intensity of A. galli. An association of the MHC with the specific antibody response to S. Enteritidis was also found where four MHC haplotypes were show...Continue Reading

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Citations

Mar 9, 2011·Developmental and Comparative Immunology·Anna SchwarzSilke Rautenschlein
Mar 5, 2015·Immunogenetics·Gholamreza Nikbakht, Atefeh Esmailnejad
Feb 2, 2016·Poultry Science·J E FultonM E Berres
Sep 30, 2020·Poultry Science·Prabuddha ManjulaJun Heon Lee
Sep 11, 2021·Genetics, Selection, Evolution : GSE·Elaheh Rostamzadeh MahdabiMasood Asadi Fozi
Apr 30, 2017·Poultry Science·J E FultonM Honkatukia

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