PMID: 6977489Jan 1, 1982Paper

MHC restriction of male-antigen-specific T helper cells collaborating in antibody responses

Immunogenetics
S PetterssonA Coutinho

Abstract

By priming female C57BL/6 mice with syngeneic male spleen cells and enriching inguinal and paraaortic lymph node cells in long-term culture (LTC) by repeated restimulations, H-Y-specific T helper cells can be produced. In response to male spleen cells carrying I-Ab antigens these cells activate "antigen-expressing" B cells to secrete polyclonal antibody. Before the end of the second week in LTC it was impossible to detect any helper activity. Induction of plaque-forming cells (PFC) also requires simultaneous recognition of antigen and I-A-encoded determinants in the "stimulator-responder" spleen-cell population. The testing of spleen cells from H-2 recombinant strains as "stimulator-responders" to anti-H-Y helper T cells of C57BL/6 origin also revealed that other genes, telomeric to I-A, control the magnitude of both specific T-cell proliferation and helper-dependent B-cell activation.

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Citations

Jul 1, 1988·Journal of Clinical Immunology·S J AndersonA R Lawton
Jul 1, 1984·European Journal of Immunology·R Zamoyska, H Waldmann
Sep 1, 1983·Scandinavian Journal of Immunology·G PoborA Coutinho
Jan 1, 1982·Immunological Reviews·A CoutinhoS Pettersson
Apr 1, 1984·Immunological Reviews·A CoutinhoC Martinez
Apr 1, 1986·European Journal of Immunology·P PereiraA Coutinho
Sep 1, 1985·Scandinavian Journal of Immunology·L Forni
Mar 1, 1983·European Journal of Immunology·S PetterssonA Coutinho

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