MHCA with SACP versus DHCA in Pediatric Aortic Arch Surgery: A Comparative Study

Scientific Reports
Ling XieHarness Lynn

Abstract

The safety and efficacy of selective antegrade cerebral perfusion (SACP) in children undergoing aortic arch surgery are unclear. In this retrospective analysis, we compared moderate hypothermic circulatory arrest (MHCA; n = 61) plus SACP vs deep hypothermic circulatory arrest (DHCA; n = 53) in children undergoing aortic arch surgery during a period from January 2008 to December 2017. Demographic characteristics and the underlying anomalies were comparable between the two groups. The MHCA + SACP group had shorter cardiopulmonary bypass (CPB) time (146.9 ± 40.6 vs 189.6 ± 41.2 min for DHCA; p < 0.05) and higher nasopharyngeal temperature (26.0 ± 2.1 vs 18.9 ± 1.6 °C; p < 0.01). The MHCA + SACP group had lower rate of neurologic complications (3/61 vs 10/53 for DHCA; p < 0.05) but not complications in other organ systems. The MHCA + SACP group also had less 24-hour chest drainage (median, interquartile rage: 28.9, 12.6-150.0 vs 47.4, 15.2-145.0 ml/kg for DHCA; p < 0.05), shorter duration of postoperative mechanical ventilation (35.0, 15.4-80.3 vs 94.0, 42.0-144.0 h; p < 0.01), and shorter stay in intensive care unit (3.9, 3.0-7.0 vs 7.7, 5.0-15.0 d; p < 0.05). In regression analysis, in-hospital mortality was associated with longe...Continue Reading

References

Jun 19, 2001·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·R Di BartolomeoA Pierangeli
Jul 18, 2002·The Annals of Thoracic Surgery·Teruhisa KazuiKatsushi Yamashita
Jan 24, 2006·The Annals of Thoracic Surgery·Hiroyuki KamiyaMatthias Karck
Jul 22, 2006·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Nawid KhaladjChristian Hagl
Nov 7, 2006·Annals of Vascular Surgery·Jean-Philippe VerhoyeJean-Pierre Favre
May 9, 2007·Seminars in Cardiothoracic and Vascular Anesthesia·Emad B MossadJohn Apostolakis
Oct 25, 2008·Journal of Cardiothoracic and Vascular Anesthesia·Stefano SalisErminio Sisillo
Jul 31, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Christian D EtzRandall B Griepp
Sep 22, 2009·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Aaron Matthew Ranasinghe, Robert Stuart Bonser
Oct 2, 2009·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Michael G GaiesJennifer C Hirsch
Mar 9, 2010·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tomas TlaskalVladimir Kucera
Jun 28, 2011·The Annals of Thoracic Surgery·Mohamed LyAlain Serraf
Nov 15, 2011·The Annals of Thoracic Surgery·Julia K GunnLara S Shekerdemian
Jul 31, 2012·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Fabian EmrichMartin Marek Kostelka
Dec 26, 2012·The Journal of Thoracic and Cardiovascular Surgery·David SpielvogelSteven L Lansman
Jan 15, 2013·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Tomoaki SuzukiMasato Hayakawa
Apr 15, 2014·The Annals of Thoracic Surgery·Christian PizarroEdward Woodford
Jul 5, 2015·European Journal of Cardio-thoracic Surgery : Official Journal of the European Association for Cardio-thoracic Surgery·Igor A KornilovAlexander Y Omelchenko
Aug 9, 2016·Seminars in Cardiothoracic and Vascular Anesthesia·Maung Hlaing
Mar 25, 2019·The Journal of Thoracic and Cardiovascular Surgery·Irbaz HameedMario Gaudino

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