PMID: 6410447Jan 1, 1983Paper

Mianserin: cardiovascular effects in elderly patients

Psychopharmacology
M MøllerL F Gram

Abstract

Cardiovascular effects of the tetracyclic antidepressant drug mianserin were examined in a prospective study including ten elderly depressed patients (age 60-77 years). During 1 week on placebo and 5 weeks on mianserin, 60 mg per day, orthostatic blood pressure testing, recording of standard electrocardiogram, 24-h electrocardiographic recording and systolic time intervals were carried out along with frequent monitoring of plasma levels of mianserin (13-57 micrograms/l) and the primary metabolite desmethylmianserin (7-27 micrograms/l). Mianserin caused a significant increase in orthostatic systolic blood pressure drop, and this correlated well with the plasma mianserin levels (rs = 0.70). There were no significant changes in supine blood pressure or in orthostatic changes in heart rate. No cardiac conduction disturbances or arrhythmias were provoked, but mianserin caused changes in systolic time intervals indicating impairment of left ventricular contractility and performance. Like tricyclic antidepressants mianserin should thus be used with caution in patients with latent or overt cardiovascular disease.

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Citations

Jan 1, 1985·Psychopharmacology·P ChristensenP Kragh-Sørensen
May 1, 1985·Journal of Affective Disorders·P ChristensenH Y Thomsen
Apr 15, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Yoram BarakRonit Weizman
Jan 1, 1989·Psychological Medicine. Monograph Supplement·S J WarringtonM Lader
Sep 6, 2002·Epidemiologia e psichiatria sociale·Riccardo Torta, Angela Scalabrino
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Jun 26, 2009·Drugs & Aging·Adam DarowskiDavid J Chambers
Oct 1, 2005·Nordic Journal of Psychiatry·Kurt Bjerregaard Bjerregaard Stage, UNKNOWN Danish University Antidepressant Group
Sep 1, 1991·Human & Experimental Toxicology·B CarconeJ Descotes
Oct 7, 2017·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Seetal DoddMichael Berk
Jun 28, 2002·Acta Psychiatrica Scandinavica·K B StageUNKNOWN Danish University Antidepressant Group
Aug 21, 2021·Frontiers in Cardiovascular Medicine·Anna CalviAderville Cabassi

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