PMID: 16613344Apr 15, 2006Paper

MIB-1 and MCM-2 immunohistochemical analysis does not aid in identification of serrated colorectal polyps with abnormal proliferation

American Journal of Clinical Pathology
David GrayHagen Blaszyk

Abstract

We investigated the staining characteristics of serrated polyps with abnormal proliferation (SPAP) using MIB-1 and MCM-2 to determine if they could provide assistance in delineating SPAPs from traditional hyperplastic polyps (HPs). Using published morphologic criteria we reviewed H&E slides of 107 polyps from 80 patients. Thirty-nine (36.4%) polyps met the criteria for SPAP Within a given region, polyps in the transverse colon had the largest percentage of SPAPs (50.0%) followed by the right colon (40.9%). The majority of SPAPs (82.1%) and HPs (72.1%) showed MIB-1 staining confined to the basal third of the crypts. The majority of SPAPs (59.0%) and HPs (52.9%) showed MCM-2 staining extending into the apical third of the crypts. We do not recommend MIB-1 or MCM-2 staining to differentiate SPAPs from conventional HPs, since staining characteristics are not significantly different between the 2 groups, and frequent variable crypt staining within a given polyp is difficult to interpret.

Citations

May 19, 2007·American Journal of Clinical Pathology·Katharina GlatzHagen Blaszyk
Mar 18, 2017·Human Pathology·Danielle FortunaJuan Palazzo
Dec 29, 2007·The American Journal of Surgical Pathology·Emina Emilia TorlakovicDale C Snover
May 29, 2007·The American Journal of Surgical Pathology·Matthias EiberArndt Hartmann

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