PMID: 9174144May 1, 1997Paper

MICA gene and ankylosing spondylitis: linkage analysis via a transmembrane-encoded triplet repeat polymorphism

Tissue Antigens
K GotoHidetoshi Inoko

Abstract

In order to address the possibility that the MICA gene located 47 kb upstream from HLA-B is involved in the pathogenesis of ankylosing spondylitis (AS), we have investigated microsatellite polymorphism in the transmembrane region of MICA in Caucasian patients with AS. The microsatellite allele consisting of 4 repetitions of GCT/AGC was present at significantly higher frequency in the patient group (Pc<0.0000001) than in the ethnically matched control group. However, the frequency of the (GCT/AGC)4 allele was significantly low in the B27-positive patients than in the B27-positive healthy controls (Pc=0.0145). These observations suggest that B27 itself remains the primary genetic marker for AS, although the significantly dissimilar phenotype frequency of the (GCT/AGC)4 allele in B27-positive patients and healthy individuals may reflect the existence of other genetic factor(s) in the HLA-B27 haplotype involved in the development of AS.

References

Apr 28, 1973·Lancet·D A BrewertonR D Sturrock
Apr 5, 1973·The New England Journal of Medicine·L SchlossteinC M Pearson
Jan 1, 1984·Rheumatology International·A BedendoS Todesco
Jul 5, 1994·Proceedings of the National Academy of Sciences of the United States of America·S BahramT Spies
Jan 1, 1996·Immunogenetics·N FodilS Bahram
Jun 1, 1996·Research in Immunology·S Bahram, T Spies

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Citations

Jun 16, 2001·Arthritis and Rheumatism·A MartinezE G de la Concha
Apr 2, 1998·Current Opinion in Immunology·J A López de Castro
Jun 29, 2001·Trends in Immunology·H A Stephens
Jul 15, 2009·Genetic Testing and Molecular Biomarkers·Shigehiro TamakiTadaaki Kirita
Jul 20, 1999·Current Opinion in Rheumatology·S GonzálezC López-Larrea
Sep 14, 2001·Current Opinion in Rheumatology·J D ReveilleM A Khan
Nov 20, 1998·Tissue Antigens·A Foissac, A Cambon-Thomsen
Dec 1, 2001·Modern Rheumatology·N K Mehra, U Kanga
Apr 22, 2011·Annals of Human Biology·V DurmanováM Buc
Feb 16, 2010·Trends in Molecular Medicine·Mun-Kit Choy, Maude E Phipps
Oct 28, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Shigehiro TamakiTadaaki Kirita
Apr 17, 2004·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·Z GrubićV Kerhin-Brkljacić
Jun 15, 2007·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Shigehiro TamakiTadaaki Kirita
May 16, 2006·Human Immunology·Judith ReindersMarcel G J Tilanus
Feb 14, 2002·European Journal of Immunogenetics : Official Journal of the British Society for Histocompatibility and Immunogenetics·M Pérez-RodríguezJ Alejandro Madrigal
May 10, 2000·Journal of Pediatric Endocrinology & Metabolism : JPEM·Y J LeeJ G Chang
Mar 30, 2013·Journal of the American Society of Nephrology : JASN·Pierre TonnerreBéatrice Charreau
Sep 29, 1998·Nature·H E PoulsenJ L Ravanat
May 20, 2014·Clinical Rheumatology·John D Reveille
Feb 11, 2016·The Open Rheumatology Journal·Qingwen Wang, Xiaodong Zhou
Apr 4, 2002·Tissue Antigens·J GlasE D Albert
Apr 4, 2000·Tissue Antigens·M Pérez-RodríguezJ A Madrigal
Jul 11, 2003·World Journal of Gastroenterology : WJG·Shou-Chuan ShihChin-Roa Kao
May 22, 2002·Annals of the New York Academy of Sciences·A Shtauvere-BrameusC B Sanjeevi
Aug 23, 2002·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Liu Chung-JiChang Kuo-Wei

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