MICA polymorphism in a northern Chinese Han population: The identification of a new MICA allele, MICA*059

Human Immunology
Wei TianLi X Li

Abstract

The major histocompatibility complex class I chain-related gene A (MICA) in humans, located 46 kb centromeric to human leukocyte antigen (HLA)-B, is highly polymorphic. In addition to its primary role in immune surveillance, recent data highlight the importance of MICA in organ transplantation and in susceptibility to some diseases. In this study, 104 healthy, unrelated Han subjects recruited from central Inner Mongolia Autonomous Region, northern China, were investigated by sequence-based typing and fragment analysis for MICA allelic variation, MICA-HLA-B linkage disequilibrium, and HLA-A-Cw-B-MICA haplotypic diversity. Nineteen MICA alleles were observed, the most frequent of which were MICA*00801, MICA*010, MICA*00201, MICA*00901, and MICA*045, with gene frequencies of 23.08%, 18.75%, 12.02%, 12.02%, and 8.17%, respectively. The peculiarity in HLA-B-MICA haplotypic configurations was also uncovered. In particular, there was a clear-cut dichotomy between MICA*00801 and MICA*045 in their linkage to members of HLA-B*13 lineage, which was frequently represented in this population. A new MICA allele, MICA*059, was identified, which appeared to be evolutionarily linked to MICA*045. Haplotype HLA-A*30-Cw*06-B*1302-MICA*00801, previ...Continue Reading

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Citations

Feb 6, 2013·Human Immunology·FengHua PanWei Tian
Mar 1, 2012·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Zheng GongShi-Ping Wang
May 25, 2010·Tissue Antigens·Steven G E Marsh, UNKNOWN WHO Nomenclature Committee for Factors of the HLA System
Apr 5, 2013·International Journal of Immunogenetics·F H PanW Tian
Aug 19, 2015·Immunological Reviews·Raphael Carapito, Seiamak Bahram
Mar 31, 2016·Scandinavian Journal of Immunology·W Y WangF Wang
Jun 9, 2016·International Journal of Immunogenetics·W Y WangL X Li
Apr 4, 2017·International Journal of Immunogenetics·W Y WangL F Xing
Mar 11, 2020·Frontiers in Immunology·Anja KlussmeierVinzenz Lange
May 11, 2021·Human Immunology·Vassilios BirtsasAthanassios Tsakris

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