Mice and monkeys as assay animals for Clostridium perfringens food poisoning.

Applied Microbiology
K F WeissR A Groom

Abstract

Spores and vegetative cells of Clostridium perfringens, in combination with meat or starch paste, sterile culture filtrates, lecithinase, and phosphorylcholine, were administered to mice and rhesus monkeys in an attempt both to evaluate the animals as test agents and, if possible, to elucidate the active factors producing food-poisoning symptoms caused by this organsim. Some of the preparations were administered to the monkeys by stomach tube; others, in gelatin capsules which were treated with formaldehyde so that the release of their contents was delayed and presumably reached the intestines of the animals. Any changes in intestinal passage times and in consistency of stools of the animals were observed, and the counts of C. perfringens in the feces of the monkeys previous and subsequent to treatment were recorded. The results obtained were inconclusive. Diarrhea occurred only relatively infrequently in both species, regardless of the substance fed or the mode of administration. The changes in intestinal passage times were not great, although in the monkeys there appeared to be a slight trend toward reduction as the magnitude of the bacterial load increased. Phosphorylcholine appeared to have little, if any, effect in reducin...Continue Reading

References

Mar 1, 1953·The Journal of Hygiene·B C HOBBSJ C CRUICKSHANK
Jan 1, 1954·The Journal of Infectious Diseases·G M DACKJ B KIRSNER
Jul 13, 1957·Lancet·F E DISCHE, S D ELEK
Jul 1, 1961·Applied Microbiology·R YAMAMOTOG F STEWART
May 1, 1962·Applied Microbiology·R ANGELOTTIK H LEWIS

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Citations

May 1, 1968·Journal of Bacteriology·C L DuncanD H Strong
Feb 1, 1979·Applied and Environmental Microbiology·K YamamotoG Sakaguchi
Feb 1, 1970·Applied Microbiology·R E HortonN B McCullough
Aug 1, 1969·Applied Microbiology·L D Satterlee, H W Walker

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