Mice deficient for wild-type p53-induced phosphatase 1 display elevated anxiety- and depression-like behaviors

Neuroscience
C S RuanX F Zhou

Abstract

Mood disorders are a severe health burden but molecular mechanisms underlying mood dysfunction remain poorly understood. Here, we show that wild-type p53-induced phosphatase 1 (Wip1) negatively responds to the stress-induced negative mood-related behaviors. Specifically, we show that Wip1 protein but not its mRNA level was downregulated in the hippocampus but not in the neocortex after 4 weeks of chronic unpredictable mild stress (CUMS) in mice. Moreover, the CUMS-responsive WIP1 downregulation in the hippocampus was restored by chronic treatment of fluoxetine (i.p. 20 mg/kg) along with the CUMS procedure. In addition, Wip1 knockout mice displayed decreased exploratory behaviors as well as increased anxiety-like and depression-like behaviors in mice without impaired motor activities under the non-CUMS condition. Furthermore, the Wip1 deficiency-responsive anxiety-like but not depression-like behaviors were further elevated in mice under CUMS. Although limitations like male-alone sampling and multiply behavioral testing exist, the present study suggests a potential protective function of Wip1 in mood stabilization.

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Citations

Sep 13, 2015·Brain Research·Thomas E KraheCláudio C Filgueiras
Apr 28, 2016·Experimental Neurology·Chun-Sheng RuanXin-Fu Zhou
Jul 29, 2016·Journal of Psychiatric Research·Joshua A AzevedoRobert C Thompson
Jun 18, 2016·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Yin-Yin BaiXin-Fu Zhou

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