Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction

Hormones and Behavior
Frances XinMarisa S Bartolomei

Abstract

Fetal exposure to endocrine disrupting chemicals (EDCs) has been associated with adverse neurobehavioral outcomes across the lifespan and can persist across multiple generations of offspring. However, the underlying mechanisms driving these changes are not well understood. We investigated the molecular perturbations associated with EDC-induced behavioral changes in first (F1) and second (F2) filial generations, using the model EDC bisphenol A (BPA). C57BL/6J dams were exposed to BPA from preconception until lactation through the diet at doses (10 μg/kg bw/d-lower dose or 10 mg/kg bw/d-upper dose) representative of human exposure levels. As adults, F1 male offspring exhibited increased depressive-like behavior, measured by the forced swim test, while females were unaffected. These behavioral changes were limited to the F1 generation and were not associated with altered maternal care. Transcriptome analysis by RNA-sequencing in F1 control and upper dose BPA-exposed adult male hippocampus revealed neurotransmitter systems as major pathways disrupted by developmental BPA exposure. High performance liquid chromatography demonstrated a male-specific reduction in hippocampal serotonin. Administration of the selective serotonin reuptak...Continue Reading

Citations

Sep 20, 2019·The Journal of Clinical Endocrinology and Metabolism·Amita BansalSara E Pinney
Oct 28, 2019·Frontiers in Genetics·Maureen A MalloyLaurie K Svoboda
Jul 13, 2019·Environmental Research·Ya MaHuizhen Zhang
Jan 6, 2021·Biomolecules·Marc MesnilDenis Sarrouilhe
Dec 10, 2020·Oxidative Medicine and Cellular Longevity·Dinh Nam TranEui-Bae Jeung
Mar 22, 2021·Best Practice & Research. Clinical Endocrinology & Metabolism·Ioannis BakoyiannisAntonios Stamatakis
Jan 27, 2020·Environmental Epidemiology·Julianne SkarhaJoseph M Braun
Apr 25, 2021·European Journal of Pediatrics·Sarah ZulkifliNoor Shafina Mohd Nor

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